Association Among Serum Perfluoroalkyl Chemicals, Glucose Homeostasis, and Metabolic Syndrome in Adolescents and Adults

OBJECTIVE: Perfluoroalkyl chemicals (PFCs) have been used worldwide in a variety of consumer products. The effect of PFCs on glucose homeostasis is not known. RESEARCH DESIGN AND METHODS: We examined 474 adolescents and 969 adults with reliable serum measures of metabolic syndrome profile from the N...

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Published in:Diabetes care Vol. 32; no. 4; pp. 702 - 707
Main Authors: Lin, Chien-Yu, Chen, Pau-Chung, Lin, Yu-Chuan, Lin, Lian-Yu
Format: Journal Article
Language:English
Published: Alexandria, VA American Diabetes Association 01.04.2009
Subjects:
Adolescent
adolescents
Adult
Adults
Alkanesulfonic Acids
Alkanesulfonic Acids - blood
animals
Biological and medical sciences
Birth weight
blood
Blood cholesterol
Blood pressure
blood serum
Caprylates
Caprylates - blood
Chemicals
Cholesterol
Dextrose
Diabetes. Impaired glucose tolerance
Diet
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
epidemiology
Female
Fluorocarbons
Fluorocarbons - blood
Food packaging
Glucose
Glucose metabolism
Health hazards
Health Surveys
high density lipoprotein cholesterol
Homeostasis
Human exposure
Humans
Hyperglycemia
insulin
Insulin Resistance
Male
Medical sciences
Metabolic diseases
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Metabolism
Middle Aged
Miscellaneous
National Health and Nutrition Examination Survey
Nutrition research
odds ratio
Original Research
Other metabolic disorders
perfluorocarbons
Public health. Hygiene
Public health. Hygiene-occupational medicine
Regression Analysis
Studies
Surveys
Teenagers
Young Adult
Youth
Endocrinopathy
Human
Association
Nutrition
Adolescent
Cardiovascular disease
Adult
Metabolic diseases
Serum
Metabolic syndrome
Endocrinology
Glycemia
ISSN:0149-5992, 1935-5548, 1935-5548
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Summary:OBJECTIVE: Perfluoroalkyl chemicals (PFCs) have been used worldwide in a variety of consumer products. The effect of PFCs on glucose homeostasis is not known. RESEARCH DESIGN AND METHODS: We examined 474 adolescents and 969 adults with reliable serum measures of metabolic syndrome profile from the National Health and Nutrition Examination Survey 1999-2000 and 2003-2004. RESULTS: In adolescents, increased serum perfluorononanoic acid (PFNA) concentrations were associated with hyperglycemia (odds ratio [OR] 3.16 [95% CI 1.39-7.16], P < 0.05). Increased serum PFNA concentrations also have favorable associations with serum HDL cholesterol (0.67 [0.45-0.99], P < 0.05). Overall, increased serum PFNA concentrations were inversely correlated with the prevalence of the metabolic syndrome (0.37 [0.21-0.64], P < 0.005). In adults, increased serum perfluorooctanoic acid concentrations were significantly associated with increased β-cell function (β coefficient 0.07 ± 0.03, P < 0.05). Increased serum perfluorooctane sulfate (PFOS) concentrations were associated with increased blood insulin (0.14 ± 0.05, P < 0.01), homeostasis model assessment of insulin resistance (0.14 ± 0.05, P < 0.01), and β-cell function (0.15 ± 0.05, P < 0.01). Serum PFOS concentrations were also unfavorably correlated with serum HDL cholesterol (OR 1.61 [95% CI 1.15-2.26], P < 0.05). CONCLUSIONS: Serum PFCs were associated with glucose homeostasis and indicators of metabolic syndrome. Further clinical and animal studies are warranted to clarify putative causal relationships.
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ISSN:0149-5992
1935-5548
1935-5548
DOI:10.2337/dc08-1816