Evidence of Lineage 1 and 3 West Nile Virus in Person with Neuroinvasive Disease, Nebraska, USA, 2023

West Nile virus (WNV) is the most common cause of human arboviral disease in the contiguous United States, where only lineage 1 (L1) WNV had been found. In 2023, an immunocompetent patient was hospitalized in Nebraska with West Nile neuroinvasive disease and multisystem organ failure. Testing at the...

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Vydáno v:	Emerging infectious diseases Ročník 30; číslo 10; s. 2090 - 2098
Hlavní autoři:	Davis, Emily, Velez, Jason, Hamik, Jeff, Fitzpatrick, Kelly, Haley, Jacki, Eschliman, Jeremy, Panella, Amanda, Staples, J. Erin, Lambert, Amy, Donahue, Matthew, Brault, Aaron C., Hughes, Holly R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States U.S. National Center for Infectious Diseases 01.10.2024 Centers for Disease Control and Prevention
Témata:	Asymptomatic Cardiovascular disease Case studies Central nervous system diseases co-infection Disease transmission Evidence of Lineage 1 and 3 West Nile Virus in Person with Neuroinvasive Disease, Nebraska, USA, 2023 Genetic aspects Genome, Viral Genomics Health aspects Hospitals Humans Infections lineage 3 Medical laboratories Medical research Medicine, Experimental Nebraska - epidemiology Ostomy Phylogeny Physiological aspects Proteins Public health Rabensburg virus Risk factors Type 2 diabetes Vector-borne diseases Viruses West Nile fever West Nile Fever - epidemiology West Nile Fever - virology West Nile virus West Nile virus - genetics zoonoses Nebraska United States Colorado United States > US Europe Africa Rabensburg virus viruses vector-borne infections co-infection United States West Nile virus lineage 3 West Nile neuroinvasive disease zoonoses genomic surveillance
ISSN:	1080-6040, 1080-6059, 1080-6059
On-line přístup:	Získat plný text
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Shrnutí:	West Nile virus (WNV) is the most common cause of human arboviral disease in the contiguous United States, where only lineage 1 (L1) WNV had been found. In 2023, an immunocompetent patient was hospitalized in Nebraska with West Nile neuroinvasive disease and multisystem organ failure. Testing at the Centers for Disease Control and Prevention indicated an unusually high viral load and acute antibody response. Upon sequencing of serum and cerebrospinal fluid, we detected lineage 3 (L3) and L1 WNV genomes. L3 WNV had previously only been found in Central Europe in mosquitoes. The identification of L3 WNV in the United States and the observed clinical and laboratory features raise questions about the potential effect of L3 WNV on the transmission dynamics and pathogenicity of WNV infections. Determining the distribution and prevalence of L3 WNV in the United States and any public health and clinical implications is critical.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Report-3 ObjectType-Case Study-4
ISSN:	1080-6040 1080-6059 1080-6059
DOI:	10.3201/eid3010.240595