Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023

We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. Thes...

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Vydáno v:Emerging infectious diseases Ročník 31; číslo 2; s. 215 - 221
Hlavní autoři: Chiu, Charles Y., Godasi, Raja Rama, Hughes, Holly R., Servellita, Venice, Foresythe, Kafaya, Tubati, Asritha, Zorn, Kelsey, Sidhu, Sukhman, Wilson, Michael R., Bethina, Sai Varun, Abenroth, Daniel, Cheng, Yee, Grams, Raymond, Reese, Camilla, Isada, Carlos, Thottempudi, Neeharika
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States U.S. National Center for Infectious Diseases 01.02.2025
Centers for Disease Control and Prevention
Témata:
Animals
Antibiotics
Bunyaviridae Infections - diagnosis
Bunyaviridae Infections - epidemiology
Bunyaviridae Infections - virology
bunyavirus
Case studies
Causes of
Cerebrospinal fluid
Diagnostic tests
Disease control
Disease transmission
Electroencephalography
Encephalitis Virus, California - genetics
Fatal Outcome
Female
Genetic vectors
Genomes
Glucose
High-Throughput Nucleotide Sequencing
Humans
Infection
Infections
Leukocytes
Lone Star virus
LSV
Magnetic resonance imaging
Male
Medical laboratories
Medical research
Medicine, Experimental
Meningoencephalitis
Meningoencephalitis - diagnosis
Meningoencephalitis - epidemiology
Meningoencephalitis - etiology
Meningoencephalitis - virology
Middle Aged
Phylogeny
Potosi virus
POTV
Proteins
RNA virus infections
Tuberculosis
Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023
United States - epidemiology
Vector-borne diseases
Viruses
United States
California
United States > US
San Francisco California
Ohio
mosquitoes
viruses
POTV
United States
ticks
Lone Star virus
metagenomic next-generation sequencing
Potosi virus
LSV
arthropod-borne viruses
meningoencephalitis
vector-borne infections
Amyblomma americanum tick
arboviruses
bunyavirus
Aedes albopictus mosquito
meningitis/encephalitis
mNGS
ISSN:1080-6040, 1080-6059, 1080-6059
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Shrnutí:We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. These findings highlight the power of metagenomic next-generation sequencing in broad-based, agnostic detection of emerging viral infections that test negative using conventional targeted diagnostic methods.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid3102.240831