Role of the innate immune system in the pathogenesis of multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous clinical presentations and course. MS is considered to be a T cell mediated disease but in recent years contribution of innate immune cells in mediating MS pathogenesis is being appreciated. In this review, we ha...

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Vydané v:Journal of neuroimmunology Ročník 221; číslo 1; s. 7 - 14
Hlavní autori: Gandhi, Roopali, Laroni, Alice, Weiner, Howard L.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier B.V 15.04.2010
Predmet:
Allergy and Immunology
Animals
Cytokines - metabolism
Dendritic cells
Dendritic Cells - physiology
Gamma Delta T cells
Humans
Immunity, Innate - physiology
Innate immune system
Killer Cells, Natural - physiology
Mast cells
Mast Cells - physiology
Microglia - physiology
Microglial cells
Models, Immunological
Multiple sclerosis
Multiple Sclerosis - etiology
Multiple Sclerosis - immunology
Multiple Sclerosis - pathology
Neurology
NK cells
NK T cells
T-Lymphocytes - classification
T-Lymphocytes - physiology
Multiple sclerosis
NK cells
Gamma Delta T cells
Dendritic cells
Microglial cells
NK T cells
Mast cells
Innate immune system
ISSN:0165-5728, 1872-8421, 1872-8421
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Popis
Shrnutí:Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous clinical presentations and course. MS is considered to be a T cell mediated disease but in recent years contribution of innate immune cells in mediating MS pathogenesis is being appreciated. In this review, we have discussed the role of various innate immune cells in mediating MS. In particular, we have provided an overview of potential anti-inflammatory or pro-inflammatory function of DCs, microglial Cells, NK cells, NK-T cells and gamma delta T cells along with their interaction among themselves and with myelin. Given the understanding of the role of the innate immune cells in MS, it is possible that immunotherapeutic intervention targeting these cells may provide a better and effective treatment.
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These authors contributed equally to this review.
ISSN:0165-5728
1872-8421
1872-8421
DOI:10.1016/j.jneuroim.2009.10.015