The hierarchy quorum sensing network in Pseudomonas aeruginosa

Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of th...

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Vydané v:	Protein & cell Ročník 6; číslo 1; s. 26 - 41
Hlavní autori:	Lee, Jasmine, Zhang, Lianhui
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Beijing Higher Education Press 01.01.2015 Springer Nature B.V
Predmet:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemistry 4-Butyrolactone - metabolism Bacterial Proteins - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Developmental Biology environmental factors Human Genetics IQS Iron - chemistry Iron - metabolism las Life Sciences PQS Protein Science Pseudomonas aeruginosa Pseudomonas aeruginosa - physiology quorum sensing Quorum Sensing - physiology Review rhl Signal Transduction Stem Cells Trans-Activators - metabolism Virulence quorum sensing PQS virulence environmental factors rhl IQS las
ISSN:	1674-800X, 1674-8018, 1674-8018
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Popis
Shrnutí:	Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of the pathogen to form biofilm matrix, which provides bacterial cells a protected environment withstanding various stresses including antibiotics. Quorum sensing (QS), a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection. The QS network of P. aeruginosa is organized in a multi-layered hierarchy consisting of at least four interconnected signaling mechanisms. Evidence is accumulating that the QS regulatory network not only responds to bacterial population changes but also could react to environmental stress cues. This plasticity should be taken into consideration during exploration and development of anti-QS therapeutics.
Bibliografia:	Document accepted on :2014-08-28 quorum sensing PQS virulence Document received on :2014-07-29 environmental factors rhl Pseudomonas aeruginosa IQS las ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1674-800X 1674-8018 1674-8018
DOI:	10.1007/s13238-014-0100-x