Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

We aimed to clarify the epidemiologic and clinical importance of evolutionary events that occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP causing bloodstream infections in a tertiary hospital in China during 2013-2017. We detected a subclonal shift in the dominan...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 26; no. 2; pp. 289 - 297
Main Authors:	Zhou, Kai, Xiao, Tingting, David, Sophia, Wang, Qin, Zhou, Yanzi, Guo, Lihua, Aanensen, David, Holt, Kathryn E., Thomson, Nicholas R., Grundmann, Hajo, Shen, Ping, Xiao, Yonghong
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01.02.2020 Centers for Disease Control and Prevention
Subjects:	Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents carbapenem resistance Carbapenem-Resistant Enterobacteriaceae - drug effects Carbapenem-Resistant Enterobacteriaceae - isolation & purification China China - epidemiology Chinese history Cloning Diversification Drug Resistance, Multiple, Bacterial Female Genomes Health aspects Humans Imipenem Infection Infections Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella Infections - mortality Klebsiella Infections - prevention & control Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - pathogenicity Male Medical Records Meropenem Microbial Sensitivity Tests Middle Aged Mortality Novel Subclone of Carbapenem-Resistant Patients Phylogenetics Phylogeny Pneumonia Population Prevalence recombination Retrospective Studies Sequence Type 11 with Enhanced Virulence and Transmissibility, China ST11 subclonal shift Survival Analysis Tigecycline Virulence Young Adult China Europe subclonal shift recombination bacteria carbapenem resistance virulence antimicrobial resistance China ST11 bacterial infections Klebsiella pneumoniae
ISSN:	1080-6040, 1080-6059, 1080-6059
Online Access:	Get full text
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