Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Markus Schürks and colleagues report a genome-wide association study for common migraine. They identify three new susceptibility loci at PRDM16 , TRPM8 and LRP1 . Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic...

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Bibliographic Details
Published in:	Nature genetics Vol. 43; no. 7; pp. 695 - 698
Main Authors:	Chasman, Daniel I, Schürks, Markus, Anttila, Verneri, de Vries, Boukje, Schminke, Ulf, Launer, Lenore J, Terwindt, Gisela M, van den Maagdenberg, Arn M J M, Fendrich, Konstanze, Völzke, Henry, Ernst, Florian, Griffiths, Lyn R, Buring, Julie E, Kallela, Mikko, Freilinger, Tobias, Kubisch, Christian, Ridker, Paul M, Palotie, Aarno, Ferrari, Michel D, Hoffmann, Wolfgang, Zee, Robert Y L, Kurth, Tobias
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.07.2011 Nature Publishing Group
Subjects:	631/208/205/2138 631/208/727/2000 692/699/375/226/1654 692/700/478/174 Agriculture Analysis Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 12 - genetics Chromosomes, Human, Pair 2 - genetics Cohort Studies Confidence intervals Epidemiology Female Fundamental and applied biological sciences. Psychology Gene Function Genealogy Genetic aspects Genetic Loci Genetic Predisposition to Disease Genetic susceptibility Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Headaches Human Genetics Humans letter Male Medical sciences Meta-analysis Middle Aged Migraine Migraine without Aura - epidemiology Migraine without Aura - genetics Migraine without Aura - pathology Neurology Polymorphism, Single Nucleotide - genetics Prognosis Risk Factors United States - epidemiology Vascular diseases and vascular malformations of the nervous system Womens health United States Germany Vascular disease Nervous system diseases Pain Migraine Central nervous system disease Cardiovascular disease Locus Cerebrovascular disease Cerebral disorder
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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