Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

André Uitterlinden and colleagues report loci at 9q31.2 and LIN28B associated with age at menarche from a meta-analysis of genome-wide association studies including 17,510 females from eight different population-based cohorts. We conducted a meta-analysis of genome-wide association data to detect ge...

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Veröffentlicht in:	Nature genetics Jg. 41; H. 6; S. 648 - 650
Hauptverfasser:	Perry, John R B, Stolk, Lisette, Franceschini, Nora, Lunetta, Kathryn L, Zhai, Guangju, McArdle, Patrick F, Smith, Albert V, Aspelund, Thor, Bandinelli, Stefania, Boerwinkle, Eric, Cherkas, Lynn, Eiriksdottir, Gudny, Estrada, Karol, Ferrucci, Luigi, Folsom, Aaron R, Garcia, Melissa, Gudnason, Vilmundur, Hofman, Albert, Karasik, David, Kiel, Douglas P, Launer, Lenore J, van Meurs, Joyce, Nalls, Michael A, Rivadeneira, Fernando, Shuldiner, Alan R, Singleton, Andrew, Soranzo, Nicole, Tanaka, Toshiko, Visser, Jenny A, Weedon, Michael N, Wilson, Scott G, Zhuang, Vivian, Streeten, Elizabeth A, Harris, Tamara B, Murray, Anna, Spector, Tim D, Demerath, Ellen W, Uitterlinden, André G, Murabito, Joanne M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.06.2009 Nature Publishing Group
Schlagworte:	Adolescent Age Age Factors Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Body Mass Index brief-communication Cancer Research Child Chromosome Mapping Chromosomes Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, Pair 8 - genetics Chromosomes, Human, Pair 9 - genetics Complications and side effects DNA-Binding Proteins - genetics Female Females Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic variance Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomics Human Genetics Humans Menarche Menarche - genetics Menstruation Meta-analysis Meta-Analysis as Topic Obesity Polymorphism, Single Nucleotide RNA-Binding Proteins Sexual Maturation - genetics Studies Australia Identification Association Locus Age Metaanalysis
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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Zusammenfassung:	André Uitterlinden and colleagues report loci at 9q31.2 and LIN28B associated with age at menarche from a meta-analysis of genome-wide association studies including 17,510 females from eight different population-based cohorts. We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 ( P = 1.7 × 10 −9 ), where the nearest genes include TMEM38B , FKTN , FSD1L , TAL2 and ZNF462 . The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10 −9 ), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work.
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/ng.386