Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

André Uitterlinden and colleagues report loci at 9q31.2 and LIN28B associated with age at menarche from a meta-analysis of genome-wide association studies including 17,510 females from eight different population-based cohorts. We conducted a meta-analysis of genome-wide association data to detect ge...

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Bibliographic Details
Published in:Nature genetics Vol. 41; no. 6; pp. 648 - 650
Main Authors: Perry, John R B, Stolk, Lisette, Franceschini, Nora, Lunetta, Kathryn L, Zhai, Guangju, McArdle, Patrick F, Smith, Albert V, Aspelund, Thor, Bandinelli, Stefania, Boerwinkle, Eric, Cherkas, Lynn, Eiriksdottir, Gudny, Estrada, Karol, Ferrucci, Luigi, Folsom, Aaron R, Garcia, Melissa, Gudnason, Vilmundur, Hofman, Albert, Karasik, David, Kiel, Douglas P, Launer, Lenore J, van Meurs, Joyce, Nalls, Michael A, Rivadeneira, Fernando, Shuldiner, Alan R, Singleton, Andrew, Soranzo, Nicole, Tanaka, Toshiko, Visser, Jenny A, Weedon, Michael N, Wilson, Scott G, Zhuang, Vivian, Streeten, Elizabeth A, Harris, Tamara B, Murray, Anna, Spector, Tim D, Demerath, Ellen W, Uitterlinden, André G, Murabito, Joanne M
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01.06.2009
Nature Publishing Group
Subjects:
Adolescent
Age
Age Factors
Agriculture
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Body Mass Index
brief-communication
Cancer Research
Child
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 6 - genetics
Chromosomes, Human, Pair 8 - genetics
Chromosomes, Human, Pair 9 - genetics
Complications and side effects
DNA-Binding Proteins - genetics
Female
Females
Fundamental and applied biological sciences. Psychology
Gene Function
Genetic aspects
Genetic variance
Genetic Variation
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Genomics
Human Genetics
Humans
Menarche
Menarche - genetics
Menstruation
Meta-analysis
Meta-Analysis as Topic
Obesity
Polymorphism, Single Nucleotide
RNA-Binding Proteins
Sexual Maturation - genetics
Studies
Australia
Identification
Association
Locus
Age
Metaanalysis
ISSN:1061-4036, 1546-1718, 1546-1718
Online Access:Get full text
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Summary:André Uitterlinden and colleagues report loci at 9q31.2 and LIN28B associated with age at menarche from a meta-analysis of genome-wide association studies including 17,510 females from eight different population-based cohorts. We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 ( P = 1.7 × 10 −9 ), where the nearest genes include TMEM38B , FKTN , FSD1L , TAL2 and ZNF462 . The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10 −9 ), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
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These authors contributed equally to this work.
ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/ng.386