Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia

Charles Mullighan and colleagues report a recurrent rearrangement of CRLF2 in B-progenitor and Down syndrome-associated acute lymphoblastic leukemia. Their genetic and functional evidence indicates that CRLF2 cooperates with activated JAK2 to promote leukemogenesis. Aneuploidy and translocations are...

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Bibliographic Details
Published in:	Nature genetics Vol. 41; no. 11; pp. 1243 - 1246
Main Authors:	Mullighan, Charles G, Collins-Underwood, J Racquel, Phillips, Letha A A, Loudin, Michael G, Liu, Wei, Zhang, Jinghui, Ma, Jing, Coustan-Smith, Elaine, Harvey, Richard C, Willman, Cheryl L, Mikhail, Fady M, Meyer, Julia, Carroll, Andrew J, Williams, Richard T, Cheng, Jinjun, Heerema, Nyla A, Basso, Giuseppe, Pession, Andrea, Pui, Ching-Hon, Raimondi, Susana C, Hunger, Stephen P, Downing, James R, Carroll, William L, Rabin, Karen R
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.11.2009 Nature Publishing Group
Subjects:	Acute lymphocytic leukemia Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell cycle Cell Line Chromosome aberrations Chromosome Deletion Chromosomes Down syndrome Down Syndrome - complications Down Syndrome - genetics Fundamental and applied biological sciences. Psychology Gene Function Gene mutations Gene Rearrangement Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Genomics Health aspects Hematologic and hematopoietic diseases Hospitals Human Genetics Humans Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Kinases letter Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical genetics Medical research Medical sciences Mice Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Receptors, Cytokine - chemistry Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Risk factors Studies United States Chromosomal aberration Trisomy Lymphoproliferative syndrome Acute leukemia Aneuploidy Malignant hemopathy Down syndrome Acute lymphocytic leukemia Cancer
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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