Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial

Since the 1990s, fluorouracil-based adjuvant chemotherapy has significantly reduced the risk of tumour recurrence in patients with stage III colon cancer. We aimed to assess whether the addition of cetuximab to standard adjuvant oxaliplatin, fluorouracil, and leucovorin chemotherapy (FOLFOX4) in pat...

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Bibliographic Details
Published in:	The lancet oncology Vol. 15; no. 8; pp. 862 - 873
Main Authors:	Taieb, Julien, Tabernero, Josep, Mini, Enrico, Subtil, Fabien, Folprecht, Gunnar, Van Laethem, Jean-Luc, Thaler, Josef, Bridgewater, John, Petersen, Lone Nørgård, Blons, Hélène, Collette, Laurence, Van Cutsem, Eric, Rougier, Philippe, Salazar, Ramon, Bedenne, Laurent, Emile, Jean-François, Laurent-Puig, Pierre, Lepage, Come
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.07.2014 Elsevier Limited Elsevier
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Aged Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cetuximab Chemotherapy Chemotherapy, Adjuvant Colon Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colonic Neoplasms - surgery Colorectal cancer Diarrhea - chemically induced Disease-Free Survival Drug Eruptions - etiology Exons - genetics Female Fluorouracil - adverse effects Fluorouracil - therapeutic use Hematology, Oncology and Palliative Medicine Humans Infusions, Intravenous - adverse effects Intention to Treat Analysis Leucovorin - adverse effects Leucovorin - therapeutic use Life Sciences Male Medical treatment Middle Aged Mucositis - chemically induced Neoplasm Staging Organoplatinum Compounds - adverse effects Organoplatinum Compounds - therapeutic use Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics
ISSN:	1470-2045, 1474-5488, 1474-5488
Online Access:	Get full text
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