Genome-wide association study of blood pressure and hypertension

Daniel Levy and colleagues report a meta-analysis of genome-wide association studies for blood pressure traits as part of the CHARGE consortium, reporting eight loci with replicated association to systolic and/or diastolic blood pressure, with one of these loci also associated to hypertension. Blood...

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Bibliographic Details
Published in:Nature genetics Vol. 41; no. 6; pp. 677 - 687
Main Authors: Levy, Daniel, Ehret, Georg B, Rice, Kenneth, Verwoert, Germaine C, Launer, Lenore J, Dehghan, Abbas, Glazer, Nicole L, Morrison, Alanna C, Johnson, Andrew D, Aspelund, Thor, Aulchenko, Yurii, Lumley, Thomas, Köttgen, Anna, Vasan, Ramachandran S, Rivadeneira, Fernando, Eiriksdottir, Gudny, Guo, Xiuqing, Arking, Dan E, Mitchell, Gary F, Mattace-Raso, Francesco U S, Smith, Albert V, Taylor, Kent, Scharpf, Robert B, Hwang, Shih-Jen, Sijbrands, Eric J G, Bis, Joshua, Harris, Tamara B, Ganesh, Santhi K, O'Donnell, Christopher J, Hofman, Albert, Rotter, Jerome I, Coresh, Josef, Benjamin, Emelia J, Uitterlinden, André G, Heiss, Gerardo, Fox, Caroline S, Witteman, Jacqueline C M, Boerwinkle, Eric, Wang, Thomas J, Gudnason, Vilmundur, Larson, Martin G, Chakravarti, Aravinda, Psaty, Bruce M, van Duijn, Cornelia M
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01.06.2009
Nature Publishing Group
Subjects:
Agriculture
Animal Genetics and Genomics
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blood and lymphatic vessels
Blood pressure
Blood Pressure - genetics
Cancer Research
Cardiology. Vascular system
Cardiovascular diseases
Care and treatment
Cell Line
Chromosome Mapping
Chromosomes, Human - genetics
Complications and side effects
Data analysis
Diastole - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Gene Function
Genetic aspects
Genetic Association Studies
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Health aspects
Health risks
Human Genetics
Humans
Hypertension
Hypertension - epidemiology
Hypertension - genetics
Liver - physiology
Liver - physiopathology
Lymphocytes - physiology
Medical research
Medical sciences
Meta-analysis
Meta-Analysis as Topic
Odds Ratio
Phenotype
Prevalence
Prevention
Risk Assessment
Risk factors
Sample size
Studies
Systole - genetics
United States
Netherlands
Hypertension
Cardiovascular disease
Blood pressure
Association
Hemodynamics
ISSN:1061-4036, 1546-1718, 1546-1718
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Summary:Daniel Levy and colleagues report a meta-analysis of genome-wide association studies for blood pressure traits as part of the CHARGE consortium, reporting eight loci with replicated association to systolic and/or diastolic blood pressure, with one of these loci also associated to hypertension. Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium ( n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10 −7 . The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium ( n = 34,433), four CHARGE loci attained genome-wide significance ( P < 5 × 10 −8 ) for SBP ( ATP2B1, CYP17A1, PLEKHA7, SH2B3 ), six for DBP ( ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4 ) and one for hypertension ( ATP2B1 ). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.
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These authors contributed equally
ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/ng.384