Genome-wide association study of blood pressure and hypertension

Daniel Levy and colleagues report a meta-analysis of genome-wide association studies for blood pressure traits as part of the CHARGE consortium, reporting eight loci with replicated association to systolic and/or diastolic blood pressure, with one of these loci also associated to hypertension. Blood...

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Vydané v:	Nature genetics Ročník 41; číslo 6; s. 677 - 687
Hlavní autori:	Levy, Daniel, Ehret, Georg B, Rice, Kenneth, Verwoert, Germaine C, Launer, Lenore J, Dehghan, Abbas, Glazer, Nicole L, Morrison, Alanna C, Johnson, Andrew D, Aspelund, Thor, Aulchenko, Yurii, Lumley, Thomas, Köttgen, Anna, Vasan, Ramachandran S, Rivadeneira, Fernando, Eiriksdottir, Gudny, Guo, Xiuqing, Arking, Dan E, Mitchell, Gary F, Mattace-Raso, Francesco U S, Smith, Albert V, Taylor, Kent, Scharpf, Robert B, Hwang, Shih-Jen, Sijbrands, Eric J G, Bis, Joshua, Harris, Tamara B, Ganesh, Santhi K, O'Donnell, Christopher J, Hofman, Albert, Rotter, Jerome I, Coresh, Josef, Benjamin, Emelia J, Uitterlinden, André G, Heiss, Gerardo, Fox, Caroline S, Witteman, Jacqueline C M, Boerwinkle, Eric, Wang, Thomas J, Gudnason, Vilmundur, Larson, Martin G, Chakravarti, Aravinda, Psaty, Bruce M, van Duijn, Cornelia M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.06.2009 Nature Publishing Group
Predmet:	Agriculture Animal Genetics and Genomics Arterial hypertension. Arterial hypotension Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood and lymphatic vessels Blood pressure Blood Pressure - genetics Cancer Research Cardiology. Vascular system Cardiovascular diseases Care and treatment Cell Line Chromosome Mapping Chromosomes, Human - genetics Complications and side effects Data analysis Diastole - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Function Genetic aspects Genetic Association Studies Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Health aspects Health risks Human Genetics Humans Hypertension Hypertension - epidemiology Hypertension - genetics Liver - physiology Liver - physiopathology Lymphocytes - physiology Medical research Medical sciences Meta-analysis Meta-Analysis as Topic Odds Ratio Phenotype Prevalence Prevention Risk Assessment Risk factors Sample size Studies Systole - genetics United States Netherlands Hypertension Cardiovascular disease Blood pressure Association Hemodynamics
ISSN:	1061-4036, 1546-1718, 1546-1718
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Shrnutí:	Daniel Levy and colleagues report a meta-analysis of genome-wide association studies for blood pressure traits as part of the CHARGE consortium, reporting eight loci with replicated association to systolic and/or diastolic blood pressure, with one of these loci also associated to hypertension. Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium ( n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10 −7 . The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium ( n = 34,433), four CHARGE loci attained genome-wide significance ( P < 5 × 10 −8 ) for SBP ( ATP2B1, CYP17A1, PLEKHA7, SH2B3 ), six for DBP ( ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4 ) and one for hypertension ( ATP2B1 ). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/ng.384