Incidence of and risk factors for sick sinus syndrome in the general population
Little is known about the incidence of and risk factors for sick sinus syndrome (SSS), a common indication for pacemaker implantation. This study sought to describe the epidemiology of SSS. This analysis included 20,572 participants (mean baseline age 59 years, 43% male) in the ARIC (Atherosclerosis...
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| Vydáno v: | Journal of the American College of Cardiology Ročník 64; číslo 6; s. 531 |
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| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
12.08.2014
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| ISSN: | 1558-3597, 1558-3597 |
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| Abstract | Little is known about the incidence of and risk factors for sick sinus syndrome (SSS), a common indication for pacemaker implantation.
This study sought to describe the epidemiology of SSS.
This analysis included 20,572 participants (mean baseline age 59 years, 43% male) in the ARIC (Atherosclerosis Risk In Communities) study and the CHS (Cardiovascular Health Study), who at baseline were free of prevalent atrial fibrillation and pacemaker therapy, had a heart rate of ≥ 50 beats/min unless using beta blockers, and were identified as of white or black race. Incident SSS cases were identified by hospital discharge International Classification of Disease-revision 9-Clinical Modification code 427.81 and validated by medical record review.
During an average 17 years of follow-up, 291 incident SSS cases were identified (unadjusted rate 0.8 per 1,000 person-years). Incidence increased with age (hazard ratio [HR]: 1.73; 95% confidence interval [CI]: 1.47 to 2.05 per 5-year increment), and blacks had a 41% lower risk of SSS than whites (HR: 0.59; 95% CI: 0.37 to 0.98). Incident SSS was associated with greater baseline body mass index, height, N-terminal pro-B-type natriuretic peptide, and cystatin C, with longer QRS interval, with lower heart rate, and with prevalent hypertension, right bundle branch block, and cardiovascular disease. We project that the annual number of new SSS cases in the United States will increase from 78,000 in 2012 to 172,000 in 2060.
Blacks have a lower risk of SSS than whites, and several cardiovascular risk factors were associated with incident SSS. With the aging of the population, the number of Americans with SSS will increase dramatically over the next 50 years. |
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| AbstractList | Little is known about the incidence of and risk factors for sick sinus syndrome (SSS), a common indication for pacemaker implantation.
This study sought to describe the epidemiology of SSS.
This analysis included 20,572 participants (mean baseline age 59 years, 43% male) in the ARIC (Atherosclerosis Risk In Communities) study and the CHS (Cardiovascular Health Study), who at baseline were free of prevalent atrial fibrillation and pacemaker therapy, had a heart rate of ≥ 50 beats/min unless using beta blockers, and were identified as of white or black race. Incident SSS cases were identified by hospital discharge International Classification of Disease-revision 9-Clinical Modification code 427.81 and validated by medical record review.
During an average 17 years of follow-up, 291 incident SSS cases were identified (unadjusted rate 0.8 per 1,000 person-years). Incidence increased with age (hazard ratio [HR]: 1.73; 95% confidence interval [CI]: 1.47 to 2.05 per 5-year increment), and blacks had a 41% lower risk of SSS than whites (HR: 0.59; 95% CI: 0.37 to 0.98). Incident SSS was associated with greater baseline body mass index, height, N-terminal pro-B-type natriuretic peptide, and cystatin C, with longer QRS interval, with lower heart rate, and with prevalent hypertension, right bundle branch block, and cardiovascular disease. We project that the annual number of new SSS cases in the United States will increase from 78,000 in 2012 to 172,000 in 2060.
Blacks have a lower risk of SSS than whites, and several cardiovascular risk factors were associated with incident SSS. With the aging of the population, the number of Americans with SSS will increase dramatically over the next 50 years. Little is known about the incidence of and risk factors for sick sinus syndrome (SSS), a common indication for pacemaker implantation.BACKGROUNDLittle is known about the incidence of and risk factors for sick sinus syndrome (SSS), a common indication for pacemaker implantation.This study sought to describe the epidemiology of SSS.OBJECTIVESThis study sought to describe the epidemiology of SSS.This analysis included 20,572 participants (mean baseline age 59 years, 43% male) in the ARIC (Atherosclerosis Risk In Communities) study and the CHS (Cardiovascular Health Study), who at baseline were free of prevalent atrial fibrillation and pacemaker therapy, had a heart rate of ≥ 50 beats/min unless using beta blockers, and were identified as of white or black race. Incident SSS cases were identified by hospital discharge International Classification of Disease-revision 9-Clinical Modification code 427.81 and validated by medical record review.METHODSThis analysis included 20,572 participants (mean baseline age 59 years, 43% male) in the ARIC (Atherosclerosis Risk In Communities) study and the CHS (Cardiovascular Health Study), who at baseline were free of prevalent atrial fibrillation and pacemaker therapy, had a heart rate of ≥ 50 beats/min unless using beta blockers, and were identified as of white or black race. Incident SSS cases were identified by hospital discharge International Classification of Disease-revision 9-Clinical Modification code 427.81 and validated by medical record review.During an average 17 years of follow-up, 291 incident SSS cases were identified (unadjusted rate 0.8 per 1,000 person-years). Incidence increased with age (hazard ratio [HR]: 1.73; 95% confidence interval [CI]: 1.47 to 2.05 per 5-year increment), and blacks had a 41% lower risk of SSS than whites (HR: 0.59; 95% CI: 0.37 to 0.98). Incident SSS was associated with greater baseline body mass index, height, N-terminal pro-B-type natriuretic peptide, and cystatin C, with longer QRS interval, with lower heart rate, and with prevalent hypertension, right bundle branch block, and cardiovascular disease. We project that the annual number of new SSS cases in the United States will increase from 78,000 in 2012 to 172,000 in 2060.RESULTSDuring an average 17 years of follow-up, 291 incident SSS cases were identified (unadjusted rate 0.8 per 1,000 person-years). Incidence increased with age (hazard ratio [HR]: 1.73; 95% confidence interval [CI]: 1.47 to 2.05 per 5-year increment), and blacks had a 41% lower risk of SSS than whites (HR: 0.59; 95% CI: 0.37 to 0.98). Incident SSS was associated with greater baseline body mass index, height, N-terminal pro-B-type natriuretic peptide, and cystatin C, with longer QRS interval, with lower heart rate, and with prevalent hypertension, right bundle branch block, and cardiovascular disease. We project that the annual number of new SSS cases in the United States will increase from 78,000 in 2012 to 172,000 in 2060.Blacks have a lower risk of SSS than whites, and several cardiovascular risk factors were associated with incident SSS. With the aging of the population, the number of Americans with SSS will increase dramatically over the next 50 years.CONCLUSIONSBlacks have a lower risk of SSS than whites, and several cardiovascular risk factors were associated with incident SSS. With the aging of the population, the number of Americans with SSS will increase dramatically over the next 50 years. |
| Author | deFilippi, Chris Alonso, Alvaro Chen, Lin Y Heckbert, Susan R Folsom, Aaron R Gronroos, Noelle N Jensen, Paul N |
| Author_xml | – sequence: 1 givenname: Paul N surname: Jensen fullname: Jensen, Paul N organization: Cardiovascular Health Research Unit, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington – sequence: 2 givenname: Noelle N surname: Gronroos fullname: Gronroos, Noelle N organization: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota – sequence: 3 givenname: Lin Y surname: Chen fullname: Chen, Lin Y organization: Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota – sequence: 4 givenname: Aaron R surname: Folsom fullname: Folsom, Aaron R organization: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota – sequence: 5 givenname: Chris surname: deFilippi fullname: deFilippi, Chris organization: Department of Medicine, University of Maryland, Baltimore, Maryland – sequence: 6 givenname: Susan R surname: Heckbert fullname: Heckbert, Susan R organization: Cardiovascular Health Research Unit, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington; Department of Pharmacy, University of Washington, Seattle, Washington – sequence: 7 givenname: Alvaro surname: Alonso fullname: Alonso, Alvaro email: alonso@umn.edu organization: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota. Electronic address: alonso@umn.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25104519$$D View this record in MEDLINE/PubMed |
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| Snippet | Little is known about the incidence of and risk factors for sick sinus syndrome (SSS), a common indication for pacemaker implantation.
This study sought to... Little is known about the incidence of and risk factors for sick sinus syndrome (SSS), a common indication for pacemaker implantation.BACKGROUNDLittle is known... |
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| SubjectTerms | Aged Aged, 80 and over Black People - ethnology Cohort Studies Female Follow-Up Studies Humans Incidence Male Middle Aged Population Surveillance - methods Prospective Studies Risk Factors Sick Sinus Syndrome - diagnosis Sick Sinus Syndrome - epidemiology Sick Sinus Syndrome - ethnology White People - ethnology |
| Title | Incidence of and risk factors for sick sinus syndrome in the general population |
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