SARS-CoV-2 variant-specific differences in inhibiting the effects of the PKR-activated integrated stress response

•SARS-CoV-2 triggers the integrated stress response through activation of PKR.•Omicron induces more stress granule formation than Delta or Ancestral SARS-CoV-2.•ISR inhibition negatively affects SARS-CoV-2 replication. The integrated stress response (ISR) is a eukaryotic cell pathway that triggers t...

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Bibliographic Details
Published in:	Virus research Vol. 339; p. 199271
Main Authors:	Christ, Wanda, Klingström, Jonas, Tynell, Janne
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 2024 Elsevier
Subjects:	COVID-19 - virology eIF-2 Kinase - metabolism eukaryotic cells Humans Integrated stress response nucleocapsid proteins Omicron pathogenesis Phosphorylation SARS-COV-2 SARS-COV-2 variants Severe acute respiratory syndrome coronavirus 2 Stress granules stress response Stress, Physiological Translational arrest viruses Translational arrest SARS-COV-2 variants Omicron Integrated stress response SARS-COV-2 Stress granules
ISSN:	0168-1702, 1872-7492, 1872-7492
Online Access:	Get full text
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