Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases 1 – 4 . Pathophysiology remains elusive and therapeuti...

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Bibliographic Details
Published in:	Nature medicine Vol. 26; no. 2; pp. 236 - 243
Main Authors:	Kim, Doyoung, Kobayashi, Tetsuro, Voisin, Benjamin, Jo, Jay-Hyun, Sakamoto, Keiko, Jin, Seon-Pil, Kelly, Michael, Pasieka, Helena B., Naff, Jessica L., Meyerle, Jon H., Ikpeama, Ijeoma D., Fahle, Gary A., Davis, Fred P., Rosenzweig, Sergio D., Alejo, Julie C., Pittaluga, Stefania, Kong, Heidi H., Freeman, Alexandra F., Nagao, Keisuke
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.02.2020 Nature Publishing Group
Subjects:	631/1647/514/1949 631/250 631/250/249/2510 692/308 692/420 692/420/256 692/699 692/699/249/2510 Activation Adrenal Cortex Hormones - therapeutic use Adult Animal diseases Animal models Antiviral agents Antiviral Agents - therapeutic use Antiviral drugs Autoimmune Diseases - complications Biomedical and Life Sciences Biomedicine Cancer Research Case reports CD4 antigen CD4-Positive T-Lymphocytes - cytology Cell Proliferation Cell Separation Complications and side effects Corticosteroids Deoxyribonucleic acid Disease Disease control DNA Drug Hypersensitivity Syndrome - therapy Eosinophilia Flow Cytometry Gene expression Gene sequencing Genetic aspects Genetic transcription Growth Health aspects Herpesvirus 6, Human - immunology Humans Hypersensitivity Immunological memory Immunomodulators Immunosuppressive agents Immunosuppressive Agents - therapeutic use Infectious Diseases Inflammatory diseases Letter Leukocytes, Mononuclear - cytology Lymphocytes Lymphocytes - cytology Lymphocytes T Male Memory cells Metabolic Diseases Molecular Medicine Neurosciences Pathophysiology Patients Piperidines - therapeutic use Precision medicine Pyrimidines - therapeutic use Pyrroles - therapeutic use Ribonucleic acid RNA RNA-Seq Signal Transduction Signs and symptoms Single-Cell Analysis T-Lymphocytes, Regulatory - cytology Tapering Therapy Tofacitinib Transcriptome VDJ Recombinases - metabolism United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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