Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses

A direct approach to limit airborne viral transmissions is to inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207–222 nm)...

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Vydáno v:	Scientific reports Ročník 10; číslo 1; s. 10285 - 8
Hlavní autoři:	Buonanno, Manuela, Welch, David, Shuryak, Igor, Brenner, David J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 24.06.2020 Nature Publishing Group Nature Portfolio
Témata:	631/326 631/326/2522 631/326/596/4130 Antiviral Agents - adverse effects Betacoronavirus - radiation effects Cell Line Coronaviridae Coronavirus 229E, Human - radiation effects Coronavirus Infections - radiotherapy Coronavirus OC43, Human - radiation effects Coronaviruses COVID-19 Disinfection - methods Health hazards Humanities and Social Sciences Humans Inactivation Influenza multidisciplinary Pandemics Particulate Matter - radiation effects Pneumonia, Viral - radiotherapy SARS Virus - radiation effects SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Ultraviolet radiation Ultraviolet Rays - adverse effects Virus Inactivation - radiation effects
ISSN:	2045-2322, 2045-2322
On-line přístup:	Získat plný text
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Popis
Shrnutí:	A direct approach to limit airborne viral transmissions is to inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207–222 nm) efficiently kills pathogens potentially without harm to exposed human tissues. We previously demonstrated that 222-nm far-UVC light efficiently kills airborne influenza virus and we extend those studies to explore far-UVC efficacy against airborne human coronaviruses alpha HCoV-229E and beta HCoV-OC43. Low doses of 1.7 and 1.2 mJ/cm 2 inactivated 99.9% of aerosolized coronavirus 229E and OC43, respectively. As all human coronaviruses have similar genomic sizes, far-UVC light would be expected to show similar inactivation efficiency against other human coronaviruses including SARS-CoV-2. Based on the beta-HCoV-OC43 results, continuous far-UVC exposure in occupied public locations at the current regulatory exposure limit (~3 mJ/cm 2 /hour) would result in ~90% viral inactivation in ~8 minutes, 95% in ~11 minutes, 99% in ~16 minutes and 99.9% inactivation in ~25 minutes. Thus while staying within current regulatory dose limits, low-dose-rate far-UVC exposure can potentially safely provide a major reduction in the ambient level of airborne coronaviruses in occupied public locations.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-67211-2