Chikungunya: a re-emerging virus

In the past decade, chikungunya—a virus transmitted by Aedes spp mosquitoes—has re-emerged in Africa, southern and southeastern Asia, and the Indian Ocean Islands as the cause of large outbreaks of human disease. The disease is characterised by fever, headache, myalgia, rash, and both acute and pers...

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Veröffentlicht in:	The Lancet (British edition) Jg. 379; H. 9816; S. 662 - 671
Hauptverfasser:	Burt, Felicity J, Rolph, Micheal S, Rulli, Nestor E, Mahalingam, Suresh, Heise, Mark T
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Kidlington Elsevier Ltd 18.02.2012 Elsevier Elsevier Limited
Schlagworte:	Aedes Aedes albopictus Africa Africa - epidemiology Alphavirus Infections - complications Alphavirus Infections - diagnosis Alphavirus Infections - drug therapy Alphavirus Infections - epidemiology Alphavirus Infections - prevention & control Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Antibodies, Viral - administration & dosage Antiviral Agents - administration & dosage Aquatic insects Arthralgia - virology Asia Asia - epidemiology Biological and medical sciences Chikungunya Fever Chikungunya virus Chikungunya virus - drug effects Chikungunya virus - immunology Chikungunya virus - pathogenicity Chloroquine - administration & dosage Communicable Diseases, Emerging - complications Communicable Diseases, Emerging - diagnosis Communicable Diseases, Emerging - drug therapy Communicable Diseases, Emerging - epidemiology Communicable Diseases, Emerging - prevention & control diagnostic techniques Disease Outbreaks Epidemics Europe Europe - epidemiology fever General aspects headache human diseases Humans Indian Ocean Islands Indian Ocean Islands - epidemiology Insect Vectors Internal Medicine Medical sciences morbidity Mosquitoes pathogenesis Ribavirin - administration & dosage risk Tropical environments tropics Vaccines Vector-borne diseases Viral Vaccines - administration & dosage viremia viruses Indian Ocean Islands Asia Europe Africa Tanzania INW, Asia ANE, Europe ISW, Indian Ocean Virus Medicine Togaviridae Alphavirus Chikungunya virus
ISSN:	0140-6736, 1474-547X, 1474-547X
Online-Zugang:	Volltext
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Zusammenfassung:	In the past decade, chikungunya—a virus transmitted by Aedes spp mosquitoes—has re-emerged in Africa, southern and southeastern Asia, and the Indian Ocean Islands as the cause of large outbreaks of human disease. The disease is characterised by fever, headache, myalgia, rash, and both acute and persistent arthralgia. The disease can cause severe morbidity and, since 2005, fatality. The virus is endemic to tropical regions, but the spread of Aedes albopictus into Europe and the Americas coupled with high viraemia in infected travellers returning from endemic areas increases the risk that this virus could establish itself in new endemic regions. This Seminar focuses on the re-emergence of this disease, the clinical manifestations, pathogenesis of virus-induced arthralgia, diagnostic techniques, and various treatment modalities.
Bibliographie:	http://dx.doi.org/10.1016/S0140-6736(11)60281-X ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Review-3
ISSN:	0140-6736 1474-547X 1474-547X
DOI:	10.1016/S0140-6736(11)60281-X