Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts

A recent study in autopsy-confirmed Parkinson's disease (PD) patients and controls revived the debate about the role of PARK10 in this disorder. In an attempt to replicate these results and further understand the role of this locus in the risk and age at onset of PD, we decided to explore Neuro...

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Vydáno v:Neurobiology of aging Ročník 36; číslo 10; s. 2907.e13 - 2907.e17
Hlavní autoři: Simón-Sánchez, Javier, Heutink, Peter, Gasser, Thomas
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.10.2015
Témata:
Adult
Age of Onset
Aged
Cohort Studies
Exome - genetics
Female
Genetic Association Studies
Genetic Variation - genetics
Genotyping Techniques
Humans
Internal Medicine
Male
Middle Aged
Neurogenetics
Neurology
NeuroX
PARK10
Parkinson Disease - epidemiology
Parkinson Disease - genetics
Parkinson's disease
Risk
Sequence Analysis, DNA - methods
Whole exome sequencing
Parkinson's disease
Neurogenetics
Whole exome sequencing
NeuroX
PARK10
ISSN:0197-4580, 1558-1497
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Shrnutí:A recent study in autopsy-confirmed Parkinson's disease (PD) patients and controls revived the debate about the role of PARK10 in this disorder. In an attempt to replicate these results and further understand the role of this locus in the risk and age at onset of PD, we decided to explore NeuroX genotyping and whole exome sequencing data from 2 large independent cohorts of clinical patients and controls from the International Parkinson's Disease Genomic Consortium. A series of single-variant and gene-based aggregation (sequence kernel association test and combined multivariate and collapsing test) statistical tests suggested that common and rare genetic variation in this locus do not influence the risk or age at onset of clinical PD.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2015.07.008