Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide

Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndr...

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Bibliographic Details
Published in:Mayo Clinic proceedings Vol. 95; no. 7; pp. 1445 - 1453
Main Authors: Sanchis-Gomar, Fabian, Lavie, Carl J., Mehra, Mandeep R., Henry, Brandon Michael, Lippi, Giuseppe
Format: Journal Article
Language:English
Published: England Elsevier Inc 01.07.2020
Elsevier, Inc
Elsevier Limited
Mayo Foundation for Medical Education and Research
Subjects:
Angiotensin
Betacoronavirus
Blood coagulation factors
Cells
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - therapy
Coronaviruses
COVID-19
Disease susceptibility
Enzymes
Humans
Lavie, Carl J
Mortality
Obesity
Obesity - complications
Pandemics
Patient outcomes
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - therapy
Prognosis
Respiratory failure
SARS-CoV-2
Severe acute respiratory syndrome
Type 2 diabetes
United States > US
T2DM
ACE
HTN
OR
AF
VTE
RAAS
Ang II
ET
COVID-19
CVD
ARB
PA
SARS-CoV-2
MetS
ACEi
SNS
CKD
CHD
HF
BMI
ISSN:0025-6196, 1942-5546, 1942-5546
Online Access:Get full text
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Summary:Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Angiotensin-converting enzyme 2 expression in adipose tissue is higher than that in lung tissue, which means that adipose tissue may be vulnerable to COVID-19 infection. Obese patients also have worse outcomes with COVID-19 infection, including respiratory failure, need for mechanical ventilation, and higher mortality. Clinicians need to be more aggressive when treating obese, especially severely obese, patients with COVID-19 infection.
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ISSN:0025-6196
1942-5546
1942-5546
DOI:10.1016/j.mayocp.2020.05.006