Mitochondrial uncoupling protein gene cluster variation (UCP2–UCP3) and the risk of incident type 2 diabetes mellitus: The Women's Genome Health Study

Uncoupling protein 2, mitochondrial, (UCP2) gene variation has recently been implicated in type 2 diabetes mellitus (T2DM). To date, no prospective epidemiological data are available. The association between 14 UCP (UCP2–UCP3) gene cluster tagging-SNPs and incident T2DM was investigated in 22,715 Ca...

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Veröffentlicht in:Atherosclerosis Jg. 214; H. 1; S. 107 - 109
Hauptverfasser: Zee, Robert Y.L., Ridker, Paul M, Chasman, Daniel I.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Amsterdam Elsevier Ireland Ltd 01.01.2011
Elsevier
Schlagworte:
Associated diseases and complications
atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular
Cohort Studies
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
diagnosis
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Follow-Up Studies
Gene variation
genes
Genetic Variation
genetics
Haplotypes
Humans
Ion Channels
Ion Channels - genetics
Medical sciences
Middle Aged
Mitochondrial Proteins
Mitochondrial Proteins - genetics
Multivariate Analysis
noninsulin-dependent diabetes mellitus
Proportional Hazards Models
Prospective Studies
regression analysis
Risk
Risk Assessment
Risk factors
Type 2 diabetes
UCPs
Uncoupling Protein 2
Uncoupling Protein 3
women
Type 2 diabetes
UCPs
Risk factors
Gene variation
Endocrinopathy
Human
Metabolic diseases
Cluster
Cardiovascular disease
Vascular disease
Atherosclerosis
Risk factor
Genome
ISSN:0021-9150, 1879-1484, 1879-1484
Online-Zugang:Volltext
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Zusammenfassung:Uncoupling protein 2, mitochondrial, (UCP2) gene variation has recently been implicated in type 2 diabetes mellitus (T2DM). To date, no prospective epidemiological data are available. The association between 14 UCP (UCP2–UCP3) gene cluster tagging-SNPs and incident T2DM was investigated in 22,715 Caucasian participants of the prospective Women's Genome Health Study. All were free of known cardiovascular disease and diabetes at baseline. During a 13-year follow-up period, 1445 participants developed an incident T2DM. Multivariable Cox regression analysis was performed to investigate the relationship between genotypes and T2DM risk assuming an additive model. Stratified analysis by smoking status, and haplotype analysis were also performed. No evidence for an association of any of the tagging-SNPs tested with T2DM risk. Further investigation using stratified analysis, and haplotype-based approach showed similar null findings. The present investigation suggests that the UCP gene cluster variation may not be useful predictor for T2DM risk assessment.
Bibliographie:http://dx.doi.org/10.1016/j.atherosclerosis.2010.10.016
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ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2010.10.016