Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study

Gestational exposure to several common agricultural pesticides can induce developmental neurotoxicity in humans, and has been associated with developmental delay and autism. We evaluated whether residential proximity to agricultural pesticides during pregnancy is associated with autism spectrum diso...

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Vydáno v:Environmental health perspectives Ročník 122; číslo 10; s. 1103 - 1109
Hlavní autoři: Shelton, Janie F., Geraghty, Estella M., Tancredi, Daniel J., Delwiche, Lora D., Schmidt, Rebecca J., Ritz, Beate, Hansen, Robin L., Hertz-Picciotto, Irva
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States National Institute of Environmental Health Sciences 01.10.2014
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Témata:
Adult
Age
Agricultural chemicals
Agricultural commodities
Agriculture
Agrochemicals
Autism
California - epidemiology
Carbamates - toxicity
Case-Control Studies
Charge
Child development
Child development deviations
Child Development Disorders, Pervasive - epidemiology
Child, Preschool
Children's Health
Chlorpyrifos
Developmental disabilities
Developmental Disabilities - epidemiology
Disorders
Environmental aspects
Environmental Exposure - adverse effects
Environmental Exposure - statistics & numerical data
Exposure
Female
Genetics
Health aspects
Humans
Hydrocarbons, Chlorinated - toxicity
Insecticides
Land use
Male
Nervous system diseases
Neurodevelopmental disorders
Neurotoxicity
Odds Ratio
Organochlorine compounds
Organophosphates
Organophosphates - toxicity
Pesticide application
Pesticides
Pesticides - toxicity
Population
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Proximity
Pyrethrins - toxicity
Pyrethroids
Questionnaires
Residence Characteristics
Risk
Risk factors
Software
Studies
California
Southern California
United States > US
ISSN:0091-6765, 1552-9924, 1552-9924
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Shrnutí:Gestational exposure to several common agricultural pesticides can induce developmental neurotoxicity in humans, and has been associated with developmental delay and autism. We evaluated whether residential proximity to agricultural pesticides during pregnancy is associated with autism spectrum disorders (ASD) or developmental delay (DD) in the Childhood Autism Risks from Genetics and Environment (CHARGE) study. The CHARGE study is a population-based case-control study of ASD, DD, and typical development. For 970 participants, commercial pesticide application data from the California Pesticide Use Report (1997-2008) were linked to the addresses during pregnancy. Pounds of active ingredient applied for organophophates, organochlorines, pyrethroids, and carbamates were aggregated within 1.25-km, 1.5-km, and 1.75-km buffer distances from the home. Multinomial logistic regression was used to estimate the odds ratio (OR) of exposure comparing confirmed cases of ASD (n = 486) or DD (n = 168) with typically developing referents (n = 316). Approximately one-third of CHARGE study mothers lived, during pregnancy, within 1.5 km (just under 1 mile) of an agricultural pesticide application. Proximity to organophosphates at some point during gestation was associated with a 60% increased risk for ASD, higher for third-trimester exposures (OR = 2.0; 95% CI: 1.1, 3.6), and second-trimester chlorpyrifos applications (OR = 3.3; 95% CI: 1.5, 7.4). Children of mothers residing near pyrethroid insecticide applications just before conception or during third trimester were at greater risk for both ASD and DD, with ORs ranging from 1.7 to 2.3. Risk for DD was increased in those near carbamate applications, but no specific vulnerable period was identified. This study of ASD strengthens the evidence linking neurodevelopmental disorders with gestational pesticide exposures, particularly organophosphates, and provides novel results of ASD and DD associations with, respectively, pyrethroids and carbamates.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0091-6765
1552-9924
1552-9924
DOI:10.1289/ehp.1307044