Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is characterized by esophageal eosinophilia, but the underlying mechanisms promoting eosinophil accumulation remain unclear. David Artis and his colleagues describe a new mouse model of EoE-like disease. The development of EoE-like disease is dependent on thymic stroma...

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Veröffentlicht in:	Nature medicine Jg. 19; H. 8; S. 1005 - 1013
Hauptverfasser:	Noti, Mario, Wojno, Elia D Tait, Kim, Brian S, Siracusa, Mark C, Giacomin, Paul R, Nair, Meera G, Benitez, Alain J, Ruymann, Kathryn R, Muir, Amanda B, Hill, David A, Chikwava, Kudakwashe R, Moghaddam, Amin E, Sattentau, Quentin J, Alex, Aneesh, Zhou, Chao, Yearley, Jennifer H, Menard-Katcher, Paul, Kubo, Masato, Obata-Ninomiya, Kazushige, Karasuyama, Hajime, Comeau, Michael R, Brown-Whitehorn, Terri, de Waal Malefyt, Rene, Sleiman, Patrick M, Hakonarson, Hakon, Cianferoni, Antonella, Falk, Gary W, Wang, Mei-Lun, Spergel, Jonathan M, Artis, David
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.08.2013 Nature Publishing Group
Schlagworte:	631/250/127 631/250/2504/223/1324 692/420/2780/262 692/699/1503/1476/1478 Adult Allergies Animals Antibodies, Monoclonal - pharmacology Basophils Basophils - drug effects Basophils - metabolism Biomedicine Cancer Research Care and treatment Causes of Cytokines Cytokines - metabolism Cytokines - pharmacology Development and progression Disease Models, Animal Eosinophilic Esophagitis - metabolism Eosinophilic Esophagitis - pathology Eosinophils Eosinophils - drug effects Eosinophils - metabolism Eosinophils - ultrastructure Esophagitis Esophagus - drug effects Esophagus - pathology Esophagus - ultrastructure Female Food allergies Genetic aspects Humans Immunoglobulin E - metabolism Immunology Infectious Diseases Inflammatory diseases Male Metabolic Diseases Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Medicine Neurosciences Neutralization Neutralization Tests Pathogenesis Physiological aspects Thymic Stromal Lymphopoietin United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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