Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation

Purpose Alpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models. Methods We evaluated the anti-inflam...

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Bibliographic Details
Published in:Lung Vol. 200; no. 4; pp. 463 - 472
Main Authors: Shahraki, Abdolrazagh Hashemi, Tian, Runxia, Zhang, Chongxu, Fregien, Nevis L., Bejarano, Pablo, Mirsaeidi, Mehdi
Format: Journal Article
Language:English
Published: New York Springer US 01.08.2022
Springer
Springer Nature B.V
Subjects:
a-Melanocyte-stimulating hormone
alpha-MSH - metabolism
alpha-MSH - pharmacology
alpha-MSH - therapeutic use
Animal models
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti-inflammatory drugs
Biochips
Biological response modifiers
Chemical compounds
Cytokines
Cytotoxicity
Epithelial cells
Epithelium
Granuloma - drug therapy
Granulomas
In vitro methods and tests
Inflammation
Inflammation - metabolism
Interferon
Intermedin
Lungs
Lymphocytes T
Macrophages
Medicine
Medicine & Public Health
Melanocyte-stimulating hormone
Mice
Pathogenesis
Pharmacology
Pneumology/Respiratory System
Sarcoidosis
Sarcoidosis - drug therapy
Sarcoidosis, Pulmonary - drug therapy
T cells
Three dimensional models
In vitro granuloma model
Bronchial epithelial cells
Type I interferons
Sarcoidosis
α-MSH
Mice model
ISSN:0341-2040, 1432-1750, 1432-1750
Online Access:Get full text
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Summary:Purpose Alpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models. Methods We evaluated the anti-inflammatory effects of α-MSH on two different in vitro sarcoidosis models (lung-on-membrane model; LOMM and three-dimensional biochip pulmonary sarcoidosis model; 3D-BSGM) generated from NBECs and an in vivo sarcoidosis mouse model. Results Treatment with α-MSH decreased inflammatory cytokine levels and downregulated type I interferon pathway genes and related proteins in LOMM and 3D-BSGM models. Treatment with α-MSH also significantly decreased macrophages and cytotoxic T-cells counts in a sarcoidosis mice model. Conclusion Our results confirm the direct role of type I IFNs in the pathogenesis of sarcoid lung granulomas and highlight α-MSH as a potential novel therapeutic agent for treating pulmonary sarcoidosis. Graphical Abstract
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ISSN:0341-2040
1432-1750
1432-1750
DOI:10.1007/s00408-022-00546-x