Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots

Background Pollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC....

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Veröffentlicht in:Journal of nanobiotechnology Jg. 15; H. 1; S. 60 - 8
Hauptverfasser: Yan, Xin, Zhao, Yan, Luo, Juan, Xiong, Wei, Liu, Xiaoman, Cheng, Jinjun, Wang, Yongzhi, Zhang, Meiling, Qu, Huihua
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 05.09.2017
BioMed Central Ltd
BMC
Schlagworte:
Animals
Biotechnology
Blood Coagulation - drug effects
Carbon - chemistry
Carbon - pharmacology
Carbon - therapeutic use
Carbon quantum dots
Charcoal - chemistry
Charcoal - pharmacology
Charcoal - therapeutic use
Charcoal drug
Chemistry
Chemistry and Materials Science
Drug discovery
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Health aspects
Hemorrhage - blood
Hemorrhage - drug therapy
Hemostasis
Hemostatics - chemistry
Hemostatics - pharmacology
Hemostatics - therapeutic use
Male
Measurement
Mice
Molecular Medicine
Nanotechnology
Plant biotechnology
Pollen
Pollen - chemistry
Pollen Typhae Carbonisata
Quantum Dots - chemistry
Quantum Dots - therapeutic use
Rats
Rats, Sprague-Dawley
Typha
Typhaceae - chemistry
Carbon quantum dots
Drug discovery
Hemostasis
Charcoal drug
Pollen Typhae Carbonisata
ISSN:1477-3155, 1477-3155
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Zusammenfassung:Background Pollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) and high-resolution TEM, as well as Fourier transform infrared, ultraviolet–visible, and fluorescence spectroscopy. Then, we assessed the anti-hemorrhagic effects and related hemostatic mechanisms of the obtained PTC-CQDs. Results The PTC-CQDs separated from PTC are spherical, monodisperse, and have a narrow size distribution between 2 and 8 nm. In the pharmacology experiment, remarkable anti-hemorrhage effects of PTC-CQDs were revealed. Additionally, the rats showed a profound decrease in activated partial thromboplastin time and increase in fibrinogen and PLT after PTC-CQDs treatment. Conclusions These results indicated the explicit hemostasis effect of PTC-CQDs, which not only provided a new idea for the material research of PTC, but have also provided new insights into potential biomedical and healthcare applications of CQDs in the field of haemorrhage control and laid a solid foundation for future drug discovery.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-017-0296-z