New roles for the BLyS/BAFF family in antigen-experienced B cell niches

BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity matura...

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Bibliographic Details
Published in:Cytokine & growth factor reviews Vol. 25; no. 2; pp. 107 - 113
Main Authors: Goenka, Radhika, Scholz, Jean L., Sindhava, Vishal J., Cancro, Michael P.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.04.2014
Subjects:
Advanced Basic Science
Antigen Presentation - immunology
B-Cell Activating Factor - immunology
B-Lymphocytes - immunology
BAFF
BLyS
Cell Differentiation - immunology
Cell Survival - immunology
Germinal center
Germinal Center - immunology
Humans
TACI
Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology
BAFF
BLyS
TACI
Germinal center
ISSN:1359-6101, 1879-0305, 1879-0305
Online Access:Get full text
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Summary:BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism.
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ISSN:1359-6101
1879-0305
1879-0305
DOI:10.1016/j.cytogfr.2014.01.001