Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study

Background Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N -formylmethionine. We hypothesized that in critically ill adults, the response to N -formylmethionine is associated with increases in metabolomic shift-related met...

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Bibliographic Details
Published in:	Critical Care Vol. 26; no. 1; pp. 321 - 13
Main Authors:	Sigurdsson, Martin Ingi, Kobayashi, Hirotada, Amrein, Karin, Nakahira, Kiichi, Rogers, Angela J., Pinilla-Vera, Mayra, Baron, Rebecca M., Fredenburgh, Laura E., Lasky-Su, Jessica A., Christopher, Kenneth B.
Format:	Journal Article
Language:	English
Published:	London Springer Science and Business Media LLC 19.10.2022 BioMed Central BioMed Central Ltd BMC
Subjects:	Acylcarnitine Adult Amino Acids, Branched-Chain Care and treatment Clinical Trials as Topic Critical Care Medicine Critical Illness Critically ill Emergency Medicine Fatty Acids Female Health aspects Hospital Mortality Humans Intensive Intensive Care Units Kynurenine Medical emergencies. Critical care. Intensive care. First aid Medicine Medicine & Public Health Metabolic shift Metabolomics Metabolomics - methods Methionine N-Formylmethionine Pentose phosphate pathway Prognosis RC86-88.9 Metabolic shift Metabolomics Critical illness Branched chain amino acids formylmethionine Acylcarnitine Pentose phosphate pathway N-formylmethionine
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
Online Access:	Get full text
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