Ketogenic diet aggravates cardiac remodeling in adult spontaneously hypertensive rats

Background Ketogenic diet (KD) has been proposed to be an effective lifestyle intervention in metabolic syndrome. However, the effects of KD on cardiac remodeling have not been investigated. Our aim was to investigate the effects and the underling mechanisms of KD on cardiac remodeling in spontaneou...

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Vydáno v:	Nutrition & metabolism Ročník 17; číslo 1; s. 91
Hlavní autoři:	You, Yuehua, Guo, Yongzheng, Jia, Ping, Zhuang, Biaobiao, Cheng, Yu, Deng, Hongpei, Wang, Xiaowen, Zhang, Cheng, Luo, Suxin, Huang, Bi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 26.10.2020 BioMed Central Ltd Springer Nature B.V BMC
Témata:	adults Antibodies Blood pressure Carbohydrates Cardiac fibrosis Cardiomyocytes Cardiovascular diseases Cell growth Clinical Nutrition Complications and side effects Development and progression Diet Fibroblasts Fibrosis Health aspects Heart Heart rate High fat diet Hypertension Ketogenesis Ketogenic diet ketone bodies Ketones Kinases Laboratory animals lifestyle Low carbohydrate diet Medicine Medicine & Public Health Metabolic Diseases Metabolic syndrome metabolism mTOR pathway mTORC2 Neonates Phosphorylation Physiological aspects Prevention Protein kinases Proteins Risk factors Rodents TOR protein China Beijing China United States > US Japan Hypertension mTOR pathway Cardiac fibrosis mTORC2 Ketogenic diet
ISSN:	1743-7075, 1743-7075
On-line přístup:	Získat plný text
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Shrnutí:	Background Ketogenic diet (KD) has been proposed to be an effective lifestyle intervention in metabolic syndrome. However, the effects of KD on cardiac remodeling have not been investigated. Our aim was to investigate the effects and the underling mechanisms of KD on cardiac remodeling in spontaneously hypertensive rats (SHRs). Methods 10-week-old spontaneously hypertensive rats were subjected to normal diet or ketogenic diet for 4 weeks. Then, their blood pressure and cardiac remodeling were assessed. Cardiac fibroblasts were isolated from 1- to 3-day-old neonatal pups. The cells were then cultured with ketone body with or without TGF-β to investigate the mechanism in vitro . Results 4 weeks of KD feeding aggravated interstitial fibrosis and cardiac remodeling in SHRs. More interestingly, ketogenic diet feeding increased the activity of mammalian target of rapamyoin (mTOR) complex 2 pathway in the heart of SHRs. In addition, β-hydroxybutyrate strengthened the progression of TGF-β-induced fibrosis in isolated cardiac fibroblasts. mTOR inhibition reversed this effect, indicating that ketone body contributes to cardiac fibroblasts via mTOR pathway. Conclusions These data suggest that ketogenic diet may lead to adverse effects on the remodeling in the hypertensive heart, and they underscore the necessity to fully evaluate its reliability before clinical use.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1743-7075 1743-7075
DOI:	10.1186/s12986-020-00510-7