Ketogenic diet aggravates cardiac remodeling in adult spontaneously hypertensive rats

Background Ketogenic diet (KD) has been proposed to be an effective lifestyle intervention in metabolic syndrome. However, the effects of KD on cardiac remodeling have not been investigated. Our aim was to investigate the effects and the underling mechanisms of KD on cardiac remodeling in spontaneou...

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Veröffentlicht in:Nutrition & metabolism Jg. 17; H. 1; S. 91
Hauptverfasser: You, Yuehua, Guo, Yongzheng, Jia, Ping, Zhuang, Biaobiao, Cheng, Yu, Deng, Hongpei, Wang, Xiaowen, Zhang, Cheng, Luo, Suxin, Huang, Bi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 26.10.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
adults
Antibodies
Blood pressure
Carbohydrates
Cardiac fibrosis
Cardiomyocytes
Cardiovascular diseases
Cell growth
Clinical Nutrition
Complications and side effects
Development and progression
Diet
Fibroblasts
Fibrosis
Health aspects
Heart
Heart rate
High fat diet
Hypertension
Ketogenesis
Ketogenic diet
ketone bodies
Ketones
Kinases
Laboratory animals
lifestyle
Low carbohydrate diet
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic syndrome
metabolism
mTOR pathway
mTORC2
Neonates
Phosphorylation
Physiological aspects
Prevention
Protein kinases
Proteins
Risk factors
Rodents
TOR protein
China
Beijing China
United States > US
Japan
Hypertension
mTOR pathway
Cardiac fibrosis
mTORC2
Ketogenic diet
ISSN:1743-7075, 1743-7075
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Zusammenfassung:Background Ketogenic diet (KD) has been proposed to be an effective lifestyle intervention in metabolic syndrome. However, the effects of KD on cardiac remodeling have not been investigated. Our aim was to investigate the effects and the underling mechanisms of KD on cardiac remodeling in spontaneously hypertensive rats (SHRs). Methods 10-week-old spontaneously hypertensive rats were subjected to normal diet or ketogenic diet for 4 weeks. Then, their blood pressure and cardiac remodeling were assessed. Cardiac fibroblasts were isolated from 1- to 3-day-old neonatal pups. The cells were then cultured with ketone body with or without TGF-β to investigate the mechanism in vitro . Results 4 weeks of KD feeding aggravated interstitial fibrosis and cardiac remodeling in SHRs. More interestingly, ketogenic diet feeding increased the activity of mammalian target of rapamyoin (mTOR) complex 2 pathway in the heart of SHRs. In addition, β-hydroxybutyrate strengthened the progression of TGF-β-induced fibrosis in isolated cardiac fibroblasts. mTOR inhibition reversed this effect, indicating that ketone body contributes to cardiac fibroblasts via mTOR pathway. Conclusions These data suggest that ketogenic diet may lead to adverse effects on the remodeling in the hypertensive heart, and they underscore the necessity to fully evaluate its reliability before clinical use.
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ISSN:1743-7075
1743-7075
DOI:10.1186/s12986-020-00510-7