IRE1 signaling affects cell fate during the unfolded protein response

Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) promote cell survival by reducing misfolded protein levels. UPR signaling also promotes apoptotic cell death if ER stress is...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 318; H. 5852; S. 944
Hauptverfasser:	Lin, Jonathan H, Li, Han, Yasumura, Douglas, Cohen, Hannah R, Zhang, Chao, Panning, Barbara, Shokat, Kevan M, Lavail, Matthew M, Walter, Peter
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 09.11.2007
Schlagworte:	Activating Transcription Factor 6 - metabolism Animals Animals, Genetically Modified Apoptosis Cell Line Cell Survival Disease Models, Animal eIF-2 Kinase - metabolism Endoplasmic Reticulum - metabolism Endoribonucleases - genetics Endoribonucleases - metabolism Humans Kinetics Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mutation Protein Folding Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins - chemistry Proteins - metabolism Rats Retina - metabolism Retinitis Pigmentosa - metabolism Rhodopsin - chemistry Rhodopsin - metabolism Signal Transduction
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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