Mitochondrial dysfunction: roles in skeletal muscle atrophy

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can lead to skeletal muscle atrophy, and its molecular mechanism leading to skeletal muscle atrop...

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Veröffentlicht in:Journal of translational medicine Jg. 21; H. 1; S. 503 - 24
Hauptverfasser: Chen, Xin, Ji, Yanan, Liu, Ruiqi, Zhu, Xucheng, Wang, Kexin, Yang, Xiaoming, Liu, Boya, Gao, Zihui, Huang, Yan, Shen, Yuntian, Liu, Hua, Sun, Hualin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 26.07.2023
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
1-Phosphatidylinositol 3-kinase
Aging
AKT protein
Analysis
Antioxidants
Atrophy
Atrophy, Muscular
Autophagy
Biomedical and Life Sciences
Biomedicine
Care and treatment
Cell therapy
Cellular Metabolism Therapy
Denervation
Diagnosis
Drug therapy
Enzymes
Gene therapy
Homeostasis
Inflammation
Insulin-like growth factor I
Insulin-like growth factors
Kinases
Medicine/Public Health
Metabolism
Methods
Mitochondria
Mitochondrial DNA
Mitochondrial dysfunction
Molecular modelling
Muscle atrophy
Musculoskeletal system
NF-κB protein
Oxidation
Oxidative stress
Physiology, Pathological
Protein synthesis
Proteins
Proteolysis
Review
SIRT1 protein
Skeletal muscle
Smad2 protein
Stat3 protein
Stem cells
Therapy
TOR protein
Transforming growth factor-b
Transplantation
Tumor necrosis factor-TNF
China
Antioxidants
Therapy
Muscle atrophy
Mitochondrial dysfunction
ISSN:1479-5876, 1479-5876
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Zusammenfassung:Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can lead to skeletal muscle atrophy, and its molecular mechanism leading to skeletal muscle atrophy is complex. Understanding the pathogenesis of mitochondrial dysfunction is useful for the prevention and treatment of skeletal muscle atrophy, and finding drugs and methods to target and modulate mitochondrial function are urgent tasks in the prevention and treatment of skeletal muscle atrophy. In this review, we first discussed the roles of normal mitochondria in skeletal muscle. Importantly, we described the effect of mitochondrial dysfunction on skeletal muscle atrophy and the molecular mechanisms involved. Furthermore, the regulatory roles of different signaling pathways (AMPK-SIRT1-PGC-1α, IGF-1-PI3K-Akt-mTOR, FoxOs, JAK-STAT3, TGF-β-Smad2/3 and NF-κB pathways, etc.) and the roles of mitochondrial factors were investigated in mitochondrial dysfunction. Next, we analyzed the manifestations of mitochondrial dysfunction in muscle atrophy caused by different diseases. Finally, we summarized the preventive and therapeutic effects of targeted regulation of mitochondrial function on skeletal muscle atrophy, including drug therapy, exercise and diet, gene therapy, stem cell therapy and physical therapy. This review is of great significance for the holistic understanding of the important role of mitochondria in skeletal muscle, which is helpful for researchers to further understanding the molecular regulatory mechanism of skeletal muscle atrophy, and has an important inspiring role for the development of therapeutic strategies for muscle atrophy targeting mitochondria in the future.
Bibliographie:ObjectType-Article-1
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ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-023-04369-z