Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

Overexpression of myo-inositol oxygenase (MIOX), a proximal tubular enzyme, exacerbates cellular redox injury in acute kidney injury (AKI). Ferroptosis, a newly coined term associated with lipid hydroperoxidation, plays a critical role in the pathogenesis of AKI. Whether or not MIOX exacerbates tubu...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 129; no. 11; pp. 5033 - 5049
Main Authors:	Deng, Fei, Sharma, Isha, Dai, Yingbo, Yang, Ming, Kanwar, Yashpal S.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.11.2019
Subjects:	Analysis Apoptosis Autophagy Biochemistry Biomarkers Biomedical research Cancer Cell death Cisplatin Diabetes DNA damage Enzymes Fatty acids Ferroptosis Genetic engineering Glutathione peroxidase Inositol Inositol oxygenase Kidney diseases Kidneys Lipid peroxidation Lipids Metabolism NADP Oxygenase Pathogenesis Peroxidase Physiological aspects Transgenic mice United States > US Nephrology Apoptosis
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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