Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

Overexpression of myo-inositol oxygenase (MIOX), a proximal tubular enzyme, exacerbates cellular redox injury in acute kidney injury (AKI). Ferroptosis, a newly coined term associated with lipid hydroperoxidation, plays a critical role in the pathogenesis of AKI. Whether or not MIOX exacerbates tubu...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	The Journal of clinical investigation Ročník 129; číslo 11; s. 5033 - 5049
Hlavní autori:	Deng, Fei, Sharma, Isha, Dai, Yingbo, Yang, Ming, Kanwar, Yashpal S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Society for Clinical Investigation 01.11.2019
Predmet:	Analysis Apoptosis Autophagy Biochemistry Biomarkers Biomedical research Cancer Cell death Cisplatin Diabetes DNA damage Enzymes Fatty acids Ferroptosis Genetic engineering Glutathione peroxidase Inositol Inositol oxygenase Kidney diseases Kidneys Lipid peroxidation Lipids Metabolism NADP Oxygenase Pathogenesis Peroxidase Physiological aspects Transgenic mice United States > US Nephrology Apoptosis
ISSN:	0021-9738, 1558-8238, 1558-8238
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!