Trophoblast organoids as a model for maternal–fetal interactions during human placentation

The placenta is the extraembryonic organ that supports the fetus during intrauterine life. Although placental dysfunction results in major disorders of pregnancy with immediate and lifelong consequences for the mother and child, our knowledge of the human placenta is limited owing to a lack of funct...

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Bibliographic Details
Published in:	Nature (London) Vol. 564; no. 7735; pp. 263 - 267
Main Authors:	Turco, Margherita Y., Gardner, Lucy, Kay, Richard G., Hamilton, Russell S., Prater, Malwina, Hollinshead, Michael S., McWhinnie, Alasdair, Esposito, Laura, Fernando, Ridma, Skelton, Helen, Reimann, Frank, Gribble, Fiona M., Sharkey, Andrew, Marsh, Steven G. E., O’Rahilly, Stephen, Hemberger, Myriam, Burton, Graham J., Moffett, Ashley
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2018 Nature Publishing Group
Subjects:	13 14 38 631/136 631/1647 Analysis Antigens Bioinformatics Cell Differentiation Cell Movement Chorionic gonadotropin Chorionic Gonadotropin - metabolism Chorionic gonadotropins Decidua Decidua - cytology Deoxyribonucleic acid DNA DNA Methylation Epithelium Female Fetuses Glycoproteins Gonadotropins Growth Differentiation Factor 15 - metabolism Histocompatibility antigen HLA HLA antigens HLA Antigens - metabolism Hormones Humanities and Social Sciences Humans Implantation Letter Leukocytes Mass spectrometry Mass spectroscopy Maternal-fetal exchange Maternal-Fetal Relations Models, Biological multidisciplinary Organoids Organoids - cytology Organoids - metabolism Organoids - physiology Peptides Physiological aspects Physiological research Pituitary (anterior) Placenta Placental hormones Placentation Pregnancy Pregnancy-Specific beta 1-Glycoproteins - metabolism Principal components analysis Science Science (multidisciplinary) Scientific imaging Secretion Spectroscopy Stem cells Surgical implants Three dimensional analysis Tissue Culture Techniques Tissue typing Transcriptome - genetics Transplants & implants Trophectoderm Trophoblasts Trophoblasts - cytology Trophoblasts - metabolism Trophoblasts - physiology
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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