Triglyceride–glucose index and the incidence of atherosclerotic cardiovascular diseases: a meta-analysis of cohort studies

Background Insulin resistance has been demonstrated to be involved in the pathogenesis of atherosclerotic cardiovascular diseases (ASCVDs). This study evaluated the association between the triglyceride–glucose (TyG) index, a novel surrogate indicator of insulin resistance, and the incidence of ASCVD...

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Veröffentlicht in:Cardiovascular diabetology Jg. 20; H. 1; S. 76 - 13
Hauptverfasser: Ding, Xiaobo, Wang, Xiaozhen, Wu, Jing, Zhang, Manli, Cui, Meizi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 03.04.2021
Springer Nature B.V
BMC
Schlagworte:
Age
Angina pectoris
Angiology
Arteriosclerosis
Asymmetry
Atherosclerosis
Atherosclerotic cardiovascular diseases
Cardiology
Cardiovascular disease
Cardiovascular diseases
Cohort analysis
Coronary artery
Coronary artery disease
Coronary vessels
Diabetes
Diabetes mellitus
Glucose
Heart diseases
Insulin
Insulin resistance
Medicine
Medicine & Public Health
Meta-analysis
Original Investigation
Population
Risk factors
Stroke
Triglyceride-glucose index
Triglyceride-glucose index
Atherosclerotic cardiovascular diseases
Insulin resistance
Coronary artery disease
Meta-analysis
ISSN:1475-2840, 1475-2840
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Zusammenfassung:Background Insulin resistance has been demonstrated to be involved in the pathogenesis of atherosclerotic cardiovascular diseases (ASCVDs). This study evaluated the association between the triglyceride–glucose (TyG) index, a novel surrogate indicator of insulin resistance, and the incidence of ASCVDs in people without ASCVDs at baseline by performing a meta-analysis. Methods Cohort studies reporting the multivariate-adjusted association between the TyG index and the incidence of ASCVDs were obtained by searching the PubMed and Embase databases. A random-effects model incorporating intra-study heterogeneity was applied to combine the results. Results Eight cohort studies comprising 5,731,294 participants were included in this meta-analysis. The results showed that compared to those with the lowest TyG index category, participants with the highest TyG index category were independently associated with a higher risk of ASCVDs [hazard ratio (HR): 1.61, 95% confidence interval (CI) 1.29–2.01, I 2  = 80%, P < 0.001]. This finding was consistent with the meta-analysis results with the TyG index analyzed as a continuous variable (HR per 1-unit increment of the TyG index: 1.39, 95% CI 1.18–1.64, I 2  = 89%, P < 0.001). Subgroup analyses suggested that the age, sex, and diabetic status did not significantly affect the association (for subgroup analyses, all P > 0.05). Moreover, participants with the highest TyG index category were independently associated with a higher risk of coronary artery disease [(CAD), HR: 1.95, 95% CI 1.47–2.58, I 2  = 92%, P < 0.001] and stroke (HR: 1.26, 95% CI 1.23–1.29, I 2  = 0%, P < 0.001). Conclusions A higher TyG index may be independently associated with a higher incidence of ASCVDs, CAD, and stroke in people without ASCVDs at baseline.
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ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-021-01268-9