Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic

Mucus-invasive bacterial biofilms are identified on the colon mucosa of approximately 50% of colorectal cancer (CRC) patients and approximately 13% of healthy subjects. Here, we test the hypothesis that human colon biofilms comprise microbial communities that are carcinogenic in CRC mouse models. Ho...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 129; no. 4; pp. 1699 - 1712
Main Authors:	Tomkovich, Sarah, Dejea, Christine M., Winglee, Kathryn, Drewes, Julia L., Chung, Liam, Housseau, Franck, Pope, Jillian L., Gauthier, Josee, Sun, Xiaolun, Mühlbauer, Marcus, Liu, Xiuli, Fathi, Payam, Anders, Robert A., Besharati, Sepideh, Perez-Chanona, Ernesto, Yang, Ye, Ding, Hua, Wu, Xinqun, Wu, Shaoguang, White, James R., Gharaibeh, Raad Z., Fodor, Anthony A., Wang, Hao, Pardoll, Drew M., Jobin, Christian, Sears, Cynthia L.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.04.2019
Subjects:	Animal models Animals Biofilms Biomedical research Biopsy Cancer patients Carcinogenesis Carcinogens Colon - metabolism Colon - microbiology Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - microbiology Colonic Neoplasms - pathology Colonoscopy Colorectal cancer Colorectal carcinoma Diagnosis Gastrointestinal diseases Gastrointestinal Microbiome Genes Genetic aspects Genetic research Genomes Germfree Humans Hypotheses Inflammation Inflammatory bowel disease Interleukin 1 Interleukin 10 Invasiveness Laboratory rats Mice Mice, Knockout Microbial mats Microbiota Microbiota (Symbiotic organisms) Mucosa Mucus Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - microbiology Neoplasms, Experimental - pathology RNA RNA sequencing rRNA 16S Tumorigenesis Tumors Oncology Bacterial infections Microbiology Mouse models Colorectal cancer
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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