Metabolic changes in aging humans: current evidence and therapeutic strategies

Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part preve...

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Vydáno v:The Journal of clinical investigation Ročník 132; číslo 16; s. 1 - 8
Hlavní autoři: Palmer, Allyson K., Jensen, Michael D.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States American Society for Clinical Investigation 15.08.2022
Témata:
Adipose Tissue
Aged
Aging
Aging - metabolism
Biomedical research
Body composition
Body fat
Caloric Restriction
Dietary restrictions
Drug metabolism
Health aspects
Humans
Longitudinal studies
Metabolism
Obesity
Older people
Physical training
Physiological aspects
Review Series
Sarcopenia
Sarcopenia - therapy
Therapeutic applications
Young adults
United States
ISSN:1558-8238, 0021-9738, 1558-8238
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Shrnutí:Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part prevented by maintenance of activity with aging. Here we explore the age-related changes seen in individual metabolic tissues - adipose, muscle, and liver - as well as globally in older adults. We also discuss the available evidence for therapeutic interventions such as caloric restriction, resistance training, and senolytic and senomorphic drugs to maintain healthy metabolism with aging, focusing on data from human studies.
Bibliografie:ObjectType-Article-1
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ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI158451