The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial

Background Peripheral neuropathy is a major adverse effect of Vincristine (VCR) in pediatric acute lymphoblastic leukemia (ALL) patients. Curcumin can prevent the development of many neurological diseases. Method This clinical trial study was conducted on 141 pediatric ALL patients, all over 5 years...

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Bibliographic Details
Published in:	BMC cancer Vol. 25; no. 1; pp. 344 - 9
Main Authors:	Eghbali, Aziz, Adibifar, Mahsa, Ghasemi, Ali, Afzal, Roghayeh Rahimi, Moradi, Katayoun, Eghbali, Aygin, Faress, Foroozan, Ghaffari, Kazem
Format:	Journal Article
Language:	English
Published:	London BioMed Central 25.02.2025 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Acute lymphoblastic leukemia Acute lymphocytic leukemia Administration, Oral Adolescent Antineoplastic Agents, Phytogenic - adverse effects Antioxidants Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Causes of Chemotherapy Child Child, Preschool Clinical trials Complications and side effects Curcumin Curcumin - administration & dosage Curcumin - therapeutic use Diabetes Dosage and administration Double-Blind Method Drug therapy Electromyography Female Health Promotion and Disease Prevention Humans Leukemia Lymphatic leukemia Lymphoma Male Medical prognosis Medicine/Public Health Neurological diseases Neuropathy Oncology Pain Parents & parenting Patients Pediatric research Pediatrics Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - prevention & control Peripheral neuropathy Pharmaceutical industry Placebos Polyneuropathies Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Sensory neurons Spinal cord Surgical Oncology Treatment Outcome Turmeric Vincristine Vincristine - administration & dosage Vincristine - adverse effects Iran Pediatrics Curcumin Neuropathy Acute lymphoblastic leukemia Vincristine
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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