The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial

Background Peripheral neuropathy is a major adverse effect of Vincristine (VCR) in pediatric acute lymphoblastic leukemia (ALL) patients. Curcumin can prevent the development of many neurological diseases. Method This clinical trial study was conducted on 141 pediatric ALL patients, all over 5 years...

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Vydáno v:	BMC cancer Ročník 25; číslo 1; s. 344 - 9
Hlavní autoři:	Eghbali, Aziz, Adibifar, Mahsa, Ghasemi, Ali, Afzal, Roghayeh Rahimi, Moradi, Katayoun, Eghbali, Aygin, Faress, Foroozan, Ghaffari, Kazem
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 25.02.2025 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Acute lymphoblastic leukemia Acute lymphocytic leukemia Administration, Oral Adolescent Antineoplastic Agents, Phytogenic - adverse effects Antioxidants Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Causes of Chemotherapy Child Child, Preschool Clinical trials Complications and side effects Curcumin Curcumin - administration & dosage Curcumin - therapeutic use Diabetes Dosage and administration Double-Blind Method Drug therapy Electromyography Female Health Promotion and Disease Prevention Humans Leukemia Lymphatic leukemia Lymphoma Male Medical prognosis Medicine/Public Health Neurological diseases Neuropathy Oncology Pain Parents & parenting Patients Pediatric research Pediatrics Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - prevention & control Peripheral neuropathy Pharmaceutical industry Placebos Polyneuropathies Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Sensory neurons Spinal cord Surgical Oncology Treatment Outcome Turmeric Vincristine Vincristine - administration & dosage Vincristine - adverse effects Iran Pediatrics Curcumin Neuropathy Acute lymphoblastic leukemia Vincristine
ISSN:	1471-2407, 1471-2407
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Shrnutí:	Background Peripheral neuropathy is a major adverse effect of Vincristine (VCR) in pediatric acute lymphoblastic leukemia (ALL) patients. Curcumin can prevent the development of many neurological diseases. Method This clinical trial study was conducted on 141 pediatric ALL patients, all over 5 years old. The subjects were randomly divided into a curcumin-treatment group and a placebo group. In the curcumin-treatment group, patients received 3 mg/kg oral curcumin capsules twice a day for 3 months. In the placebo cohort, participants were administered placebo capsules twice a day for 3 months. Administration of VCR was started in all patients in both groups, with a weekly dose of 1.5 mg/m 2 . Result Overall, 39.4% of participants in the curcumin treatment group and 70.0% in the placebo group had VIPN. Thus, a significant difference in the incidence of VIPN was observed in the two groups ( P < 0.001). A significantly higher frequency of motor nerve abnormalities in all types of nerves was observed in the placebo group than in the curcumin treatment group ( P < 0.05). Conclusions The results of our study showed that curcumin is effective in preventing the development of VIPN and leads to the improvement of VIPN in these patients. Our findings indicate that the prevalence of VIPN was substantially lower in the curcumin-treated group compared to the placebo group, as confirmed by both NCS and EMG assessments. Furthermore, curcumin demonstrated a protective effect against motor and sensory nerve damage, with a significant reduction in motor nerve abnormalities. Trial registration This study was registered at https://irct.behdasht.gov.ir/trial/73161 . Trial registration number: IRCT20201107049296N3. Date of registration: 2022-09-11.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	1471-2407 1471-2407
DOI:	10.1186/s12885-025-13751-7