A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs. Mechanistically, this occurs via Smad2‐mediated transcriptional regulation...

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Bibliographic Details
Published in:	EMBO molecular medicine Vol. 12; no. 4; pp. e11466 - n/a
Main Authors:	Cangkrama, Michael, Wietecha, Mateusz, Mathis, Nicolas, Okumura, Rin, Ferrarese, Luca, Al‐Nuaimi, Dunja, Antsiferova, Maria, Dummer, Reinhard, Innocenti, Metello, Werner, Sabine
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.04.2020 EMBO Press John Wiley and Sons Inc Springer Nature
Subjects:	activin Activin receptors Activins - metabolism Animals CAF Cancer therapies Carcinogenesis Carcinoma, Squamous Cell Cell migration EMBO03 EMBO38 Fibroblasts Filopodia Formins Gene regulation Genotype & phenotype Humans Malignancy mDia2 Mice Mice, Inbred NOD Mice, SCID Microtubule-Associated Proteins - metabolism NADPH Dehydrogenase - metabolism p53 Protein Paracrine signalling Secretome Skin cancer Smad2 protein Stroma Transcription Tumor cells tumor microenvironment Tumorigenesis Tumors CAF mDia2 tumor microenvironment activin carcinogenesis
ISSN:	1757-4676, 1757-4684, 1757-4684
Online Access:	Get full text
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