Evaluation of antioxidant, anti-inflammatory, anticancer activities and molecular docking of Moringa oleifera seed oil extract against experimental model of Ehrlich ascites carcinoma in Swiss female albino mice

The current research intended to evaluate the antitumor properties of Moringa oleifera oil extract (MOE). Fifty-six female Swiss albino mice were employed in this study. Animals were assigned into four groups: control (C) group, moringa oil extract (MOE) group administered (500 mg/kg b. wt) MOE dail...

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Veröffentlicht in:	BMC complementary and alternative medicine Jg. 23; H. 1; S. 457
Hauptverfasser:	Aldayel, Tahany Saleh, Gad El Hak, Heba N., Nafie, Mohamed S., Saad, Raneem, Abdelrazek, Heba M. A., Kilany, Omnia E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 14.12.2023 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	albino Amino acids Analysis Anti-inflammatory drugs Anticancer properties Antioxidants Antitumor activity Apoptosis Ascites Binding Body weight Cancer Cancer therapies Carcinoma Care and treatment Cell cycle Cell viability Chiropractic Medicine Cinnamic acid complement Complementary & Alternative Medicine Creatinine Cytokines Damage prevention Ehrlich ascites carcinoma Ellagic acid Females Gallic acid Glucose Hesperidin histopathology Inflammation Internal Medicine Kidney Kidneys Liquid chromatography Liver Medicine Medicine & Public Health Molecular docking Moringa oleifera Moringa olifera oil extract Oils & fats Oxidative stress Pathogenesis Proteins Quercetin seed oils Seeds Tumors Vanillin Weight reduction Antioxidants oil extract Cytokines Liver Kidney Ehrlich ascites carcinoma Moringa olifera oil extract
ISSN:	2662-7671, 2662-7671, 1472-6882
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Zusammenfassung:	The current research intended to evaluate the antitumor properties of Moringa oleifera oil extract (MOE). Fifty-six female Swiss albino mice were employed in this study. Animals were assigned into four groups: control (C) group, moringa oil extract (MOE) group administered (500 mg/kg b. wt) MOE daily via gavage, Ehrlich ascites carcinoma (EAC) group and EAC group administered daily with (500 mg/kg b.wt) MOE for two weeks (EAC/MOE). The results showed that MOE significantly ameliorated the EAC increase in body weight and reduced the EAC cell viability. In addition, they upgraded the levels of hepatic and renal functions, inflammatory cytokines, oxidative stress markers and EAC-induced hepatic and renal histopathological changes. Treatment of EAC with MOE induced antitumor, anti-inflammatory and antioxidant effects and normalized most of the tested parameters besides the histopathological alterations in both renal and hepatic tissues. HPLC for the MOE identified Cinnamic acid, Ellagic acid, Quercetin, Gallic acid, Vanillin and Hesperidin as major compounds. The molecular docking study highlighted the virtual binding of the identified compounds inside the GSH and SOD proteins, especially for Quercetin which exhibited promising binding affinity with good interactive binding mode with the key amino acids. These results demonstrate that the antitumor constituents of MOE against EAC induced oxidative stress and inflammation by preventing oxidative damage and controlling EAC increase.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2662-7671 2662-7671 1472-6882
DOI:	10.1186/s12906-023-04279-z