Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output

Reduced cardiac output is associated with increased white matter hyperintensities (WMH) and executive dysfunction in older adults, which may be secondary to relations between systemic and cerebral perfusion. This study preliminarily describes the regional distribution of cerebral WMH in the context...

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Veröffentlicht in:Neurobiology of aging Jg. 32; H. 1; S. 133 - 139
Hauptverfasser: Jefferson, Angela L., Holland, Christopher M., Tate, David F., Csapo, Istvan, Poppas, Athena, Cohen, Ronald A., Guttmann, Charles R.G.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Elsevier Inc 01.01.2011
Elsevier
Schlagworte:
Aged
Aged, 80 and over
Biological and medical sciences
Brain - diagnostic imaging
Brain - pathology
Brain Mapping
Cardiac output
Cardiac Output - physiology
Cardiovascular disease
Development. Senescence. Regeneration. Transplantation
Echocardiography, Doppler - methods
Female
Fundamental and applied biological sciences. Psychology
Heart Diseases - pathology
Heart Diseases - physiopathology
Humans
Internal Medicine
Magnetic Resonance Imaging
Male
MRI
Neurology
Perfusion
Perfusion - methods
SPECT
Statistics as Topic
Tomography, Emission-Computed, Single-Photon
Vertebrates: nervous system and sense organs
White matter hyperintensities
Cardiovascular disease
White matter hyperintensities
Cardiac output
MRI
Perfusion
SPECT
Human
Senescence
Nuclear magnetic resonance imaging
Photon
White matter
Emission tomography
ISSN:0197-4580, 1558-1497, 1558-1497
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Zusammenfassung:Reduced cardiac output is associated with increased white matter hyperintensities (WMH) and executive dysfunction in older adults, which may be secondary to relations between systemic and cerebral perfusion. This study preliminarily describes the regional distribution of cerebral WMH in the context of a normal cerebral perfusion atlas and aims to determine if these variables are associated with reduced cardiac output. Thirty-two participants (72 ± 8 years old, 38% female) with cardiovascular risk factors or disease underwent structural MRI acquisition at 1.5 T using a standard imaging protocol that included FLAIR sequences. WMH distribution was examined in common anatomical space using voxel-based morphometry and as a function of normal cerebral perfusion patterns by overlaying a single photon emission computed tomography (SPECT) atlas. Doppler echocardiogram data was used to dichotomize the participants on the basis of low ( n = 9) and normal ( n = 23) cardiac output. Global WMH count and volume did not differ between the low and normal cardiac output groups; however, atlas-derived SPECT perfusion values in regions of hyperintensities were reduced in the low versus normal cardiac output group ( p < 0.001). Our preliminary data suggest that participants with low cardiac output have WMH in regions of relatively reduced perfusion, while normal cardiac output participants have WMH in regions with relatively higher regional perfusion. This spatial perfusion distribution difference for areas of WMH may occur in the context of reduced systemic perfusion, which subsequently impacts cerebral perfusion and contributes to subclinical or clinical microvascular damage.
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ISSN:0197-4580
1558-1497
1558-1497
DOI:10.1016/j.neurobiolaging.2009.01.011