Brain regional lesion burden and impaired mobility in the elderly

This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and s...

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Veröffentlicht in:Neurobiology of aging Jg. 32; H. 4; S. 646 - 654
Hauptverfasser: Moscufo, Nicola, Guttmann, Charles R.G., Meier, Dominik, Csapo, Istvan, Hildenbrand, Peter G., Healy, Brian C., Schmidt, Julia A., Wolfson, Leslie
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Elsevier Inc 01.04.2011
Elsevier
Schlagworte:
Aged
Aged, 80 and over
Aging
Aging - pathology
Aging - physiology
Biological and medical sciences
Brain
Brain - pathology
Corona radiata
Development. Senescence. Regeneration. Transplantation
Female
Fundamental and applied biological sciences. Psychology
Gait - physiology
Humans
Image Processing, Computer-Assisted
Internal Medicine
Logistic Models
Magnetic Resonance Imaging
Male
Mobility
Nerve Fibers, Myelinated - pathology
Neurology
Prospective Studies
Splenium of corpus callosum
Vertebrates: nervous system and sense organs
Walking - physiology
White matter
White matter hyperintensity
Brain
White matter hyperintensity
Magnetic resonance imaging
Splenium of corpus callosum
Corona radiata
Aging
Mobility
White matter
Senescence
Central nervous system
Nuclear magnetic resonance imaging
Corpus callosum
Encephalon
Lesion
ISSN:0197-4580, 1558-1497, 1558-1497
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Zusammenfassung:This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed ( r = 0.4, p < 10 −4), and in logistic regression it was the best regional predictor of low mobility performance. We also found that independent of mobility, corona radiata has the largest lesion burden with anterior (ACR) and posterior (PCR) aspects being the most frequently affected. The results suggest that compromised inter-hemispheric integration of visuospatial information through the SCC plays an important role in mobility impairment in the elderly. The relatively high lesion susceptibility of ACR and PCR in all subjects may obscure the importance of these lesions in mobility impairment.
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ISSN:0197-4580
1558-1497
1558-1497
DOI:10.1016/j.neurobiolaging.2009.04.010