Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics

Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but does not capture their spatial distribution nor reveal local networks of intercellular communication acting in situ. A suite of recently developed techniques that localize RNA within tissue, including multiplexed...

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Vydané v:	Nature reviews. Genetics Ročník 22; číslo 10; s. 627 - 644
Hlavní autori:	Longo, Sophia K, Guo, Margaret G, Ji, Andrew L, Khavari, Paul A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Nature Publishing Group 01.10.2021
Predmet:	Algorithms Animals Bar codes Cell Communication Communication Computational Biology - methods Computer applications Disease Gene expression Homeostasis Humans Hybridization Ligands Ribonucleic acid RNA Sequence Analysis, RNA - methods Single-Cell Analysis - methods Software Spatial data Spatial distribution Transcription Transcriptome Transcriptomes Transcriptomics
ISSN:	1471-0056, 1471-0064, 1471-0064
On-line prístup:	Získať plný text
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