Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired vision. We conducted a meta-analysis of genome-wide association studies...

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Bibliographic Details
Published in:	Nature genetics Vol. 52; no. 4; pp. 401 - 407
Main Authors:	Hysi, Pirro G., Choquet, Hélène, Khawaja, Anthony P., Wojciechowski, Robert, Tedja, Milly S., Yin, Jie, Simcoe, Mark J., Patasova, Karina, Mahroo, Omar A., Thai, Khanh K., Cumberland, Phillippa M., Melles, Ronald B., Verhoeven, Virginie J. M., Vitart, Veronique, Segre, Ayellet, Stone, Richard A., Wareham, Nick, Hewitt, Alex W., Mackey, David A., Klaver, Caroline C. W., MacGregor, Stuart, Khaw, Peng T., Foster, Paul J., Guggenheim, Jeremy A., Rahi, Jugnoo S., Jorgenson, Eric, Hammond, Christopher J.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2020 Nature Publishing Group
Subjects:	631/208/205 631/208/212 631/208/457 692/699 Adult Aged Agriculture Analysis Animal Genetics and Genomics Biobanks Biomedical and Life Sciences Biomedicine Cancer Research Circadian rhythms Consortia Cornea Errors Eye Female Gene Function Gene loci Genes Genetic analysis Genetic diversity Genetic factors Genetic Predisposition to Disease - genetics Genetic variance Genome-wide association studies Genome-Wide Association Study - methods Genomes Genomics Heritability Human Genetics Humans Male Meta-analysis Middle Aged Molecular modelling Morbidity Mutation Myopia Myopia - genetics Pigmentation Polymorphism, Single Nucleotide - genetics Refractive errors Refractive Errors - genetics White People - genetics Europe United Kingdom > UK
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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