Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers, but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor mutational burden (TMB) may predict clinical response to ICI. To examine this association more broadly, we analyzed t...

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Veröffentlicht in:	Nature genetics Jg. 51; H. 2; S. 202 - 206
Hauptverfasser:	Samstein, Robert M., Lee, Chung-Han, Shoushtari, Alexander N., Hellmann, Matthew D., Shen, Ronglai, Janjigian, Yelena Y., Barron, David A., Zehir, Ahmet, Jordan, Emmet J., Omuro, Antonio, Kaley, Thomas J., Kendall, Sviatoslav M., Motzer, Robert J., Hakimi, A. Ari, Voss, Martin H., Russo, Paul, Rosenberg, Jonathan, Iyer, Gopa, Bochner, Bernard H., Bajorin, Dean F., Al-Ahmadie, Hikmat A., Chaft, Jamie E., Rudin, Charles M., Riely, Gregory J., Baxi, Shrujal, Ho, Alan L., Wong, Richard J., Pfister, David G., Wolchok, Jedd D., Barker, Christopher A., Gutin, Philip H., Brennan, Cameron W., Tabar, Viviane, Mellinghoff, Ingo K., DeAngelis, Lisa M., Ariyan, Charlotte E., Lee, Nancy, Tap, William D., Gounder, Mrinal M., D’Angelo, Sandra P., Saltz, Leonard, Stadler, Zsofia K., Scher, Howard I., Baselga, Jose, Razavi, Pedram, Klebanoff, Christopher A., Yaeger, Rona, Segal, Neil H., Ku, Geoffrey Y., DeMatteo, Ronald P., Ladanyi, Marc, Rizvi, Naiyer A., Berger, Michael F., Riaz, Nadeem, Solit, David B., Chan, Timothy A., Morris, Luc G. T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.02.2019 Nature Publishing Group
Schlagworte:	45/23 631/208/248 631/250/251 631/67/580 Agriculture Animal Genetics and Genomics Antineoplastic Agents - immunology Biological markers Biomarkers Biomedical and Life Sciences Biomedicine Cancer Cancer metastasis Cancer patients Cancer Research Cancer therapies Cancer treatment Gene expression Gene Function Gene mutation High-Throughput Nucleotide Sequencing - methods Histology Human Genetics Humans Immune checkpoint inhibitors Immunotherapy Immunotherapy - methods Laboratories Letter Lung cancer Melanoma Metastases Metastasis Mutation Mutation - genetics Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy Next-generation sequencing Patients Survival Tumor Burden - genetics Tumor Burden - immunology Tumors
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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