Selective breeding for endurance running capacity affects cognitive but not motor learning in rats

The ability to utilize oxygen has been shown to affect a wide variety of physiological factors often considered beneficial for survival. As the ability to learn can be seen as one of the core factors of survival in mammals, we studied whether selective breeding for endurance running, an indication o...

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Veröffentlicht in:	Physiology & behavior Jg. 106; H. 2; S. 95 - 100
Hauptverfasser:	Wikgren, Jan, Mertikas, Georgios G., Raussi, Pekka, Tirkkonen, Riina, Äyräväinen, Laura, Pelto-Huikko, Markku, Koch, Lauren G., Britton, Steven L., Kainulainen, Heikki
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Amsterdam Elsevier Inc 15.05.2012 Elsevier
Schlagworte:	Aerobic capacity Animal subjects Animals Behavioral psychophysiology Biological and medical sciences Brain Breeding Classical conditioning Cognition Cognitive ability Conditioning, Classical Discrimination Learning Endurance Female Fundamental and applied biological sciences. Psychology Learning Maze Learning Motor learning Motor skill learning Oxygen Physical Conditioning, Animal - psychology Physical Endurance Physiology Plasticity Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains Rotarod Performance Test Rules Running Running (effects) Running - psychology selection methods Survival T-maze T-maze Aerobic capacity Classical conditioning Rat Rodentia Cognitive ability Aerobe Motor learning Running locomotion Sport Vertebrata Mammalia Acquisition process Animal Endurance Motricity
ISSN:	0031-9384, 1873-507X, 1873-507X
Online-Zugang:	Volltext
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Zusammenfassung:	The ability to utilize oxygen has been shown to affect a wide variety of physiological factors often considered beneficial for survival. As the ability to learn can be seen as one of the core factors of survival in mammals, we studied whether selective breeding for endurance running, an indication of aerobic capacity, also has an effect on learning. Rats selectively bred over 23 generations for their ability to perform forced treadmill running were trained in an appetitively motivated discrimination-reversal classical conditioning task, an alternating T-maze task followed by a rule change (from a shift-win to stay-win rule) and motor learning task. In the discrimination-reversal and T-maze tasks, the high-capacity runner (HCR) rats outperformed the low-capacity runner (LCR) rats, most notably in the phases requiring flexible cognition. In the Rotarod (motor-learning) task, the HCR animals were overall more agile but learned at a similar rate with the LCR group as a function of training. We conclude that the intrinsic ability to utilize oxygen is associated especially with tasks requiring plasticity of the brain structures implicated in flexible cognition. ► Aerobic capacity correlates positively with cognitive abilities. ► It is not known whether this is due to acquired or innate aerobic capacity. ► We trained rats bred for endurance running capacity in tasks requiring flexible cognition. ► Rats with intrinsically high running capacity outperformed those with low capacity.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0031-9384 1873-507X 1873-507X
DOI:	10.1016/j.physbeh.2012.01.011