Maternal varicella antibodies in children aged less than one year: Assessment of antibody decay

To investigate maternal antibody levels to varicella in infants <12 months of age in Ontario, Canada. In this study, we included specimens from infants <12 months of age, born at [greater than or equal to]37 weeks gestational age, who had sera collected at The Hospital for Sick Children (Toron...

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Vydáno v:PloS one Ročník 18; číslo 11; s. e0287765
Hlavní autoři: Bolotin, Shelly, Hughes, Stephanie L., Savage, Rachel D., McLachlan, Elizabeth, Severini, Alberto, Arnold, Callum, Richardson, Susan, Crowcroft, Natasha S., Deek, Shelley, Halperin, Scott A., Brown, Kevin A., Hatchette, Todd, Osman, Selma, Gubbay, Jonathan B., Science, Michelle
Médium: Journal Article
Jazyk:angličtina
Vydáno: San Francisco Public Library of Science 10.11.2023
Public Library of Science (PLoS)
Témata:
Age
Antibodies
Babies
Biology and life sciences
Breastfeeding & lactation
Care and treatment
Chicken pox
Children
Confidence intervals
Diagnosis
Diseases
Emergency medical care
Enzyme-linked immunosorbent assay
Ethics
Gestational age
Glycoproteins
Health aspects
Immunoassay
Infants
Infections
Information systems
Medicine and Health Sciences
Missing data
People and Places
Prophylaxis
Regression analysis
Research and Analysis Methods
Science Policy
Serology
Statistical analysis
Vaccines
Varicella
Varicella-zoster virus
Viral antibodies
Canada
ISSN:1932-6203, 1932-6203
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Popis
Shrnutí:To investigate maternal antibody levels to varicella in infants <12 months of age in Ontario, Canada. In this study, we included specimens from infants <12 months of age, born at [greater than or equal to]37 weeks gestational age, who had sera collected at The Hospital for Sick Children (Toronto, Canada) between 2014-2016. We tested sera using a glycoprotein-based enzyme-linked immunosorbent assay (gpELISA). We measured varicella susceptibility (antibody concentration <150mIU/mL) and mean varicella antibody concentration, and assessed the probability of susceptibility and concentration between one and 11 months of age using multivariable logistic regression and Poisson regression. We found that 32% of 196 included specimens represented infants susceptible to varicella at one month of age, increasing to nearly 80% at three months of age. At six months of age, all infants were susceptible to varicella and the predicted mean varicella antibody concentration declined to 62 mIU/mL (95% confidence interval 40, 84), well below the threshold of protection. We found that varicella maternal antibody levels wane rapidly in infants, leaving most infants susceptible by four months of age. Our findings have implications for the timing of first dose of varicella-containing vaccine, infection control measures, and infant post-exposure prophylaxis recommendations.
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0287765