Long non-coding RNAs and control of gene expression in the immune system

•The expression of lncRNAs in the immune system is cell type- and context-dependent.•Several lncRNAs identified to date regulate immune gene expression.•LncRNAs play crucial role in host–pathogen interactions.•The majority of disease-associated SNPs lie in regulatory regions of the genome. All cells...

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Vydané v:Trends in molecular medicine Ročník 20; číslo 11; s. 623 - 631
Hlavní autori: Atianand, Maninjay K., Fitzgerald, Katherine A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.11.2014
Predmet:
Animals
epigenetics
gene expression
Gene Expression Regulation
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Immune System - physiology
Immunity - genetics
innate immunity
lincRNA
lncRNA
long non-coding RNA
Pathology
RNA, Long Noncoding
lincRNA
long non-coding RNA
lncRNA
innate immunity
gene expression
epigenetics
ISSN:1471-4914, 1471-499X, 1471-499X
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Shrnutí:•The expression of lncRNAs in the immune system is cell type- and context-dependent.•Several lncRNAs identified to date regulate immune gene expression.•LncRNAs play crucial role in host–pathogen interactions.•The majority of disease-associated SNPs lie in regulatory regions of the genome. All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1471-4914
1471-499X
1471-499X
DOI:10.1016/j.molmed.2014.09.002