Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional genetic screens in palbociclib-resistant cells. Using th...

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Bibliographic Details
Published in:	PloS one Vol. 17; no. 9; p. e0273182
Main Authors:	Pogacar, Ziva, Johnson, Jackie L., Krenning, Lenno, De Conti, Giulia, Jochems, Fleur, Lieftink, Cor, Velds, Arno, Wardak, Leyma, Groot, Kelvin, Schepers, Arnout, Wang, Liqin, Song, Ji-Ying, van de Ven, Marieke, van Tellingen, Olaf, Medema, Rene H., Beijersbergen, Roderick L., Bernards, Rene, Leite de Oliveira, Rodrigo
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 06.09.2022 Public Library of Science (PLoS)
Subjects:	Analysis Breast cancer Cancer Cancer therapies Care and treatment Cell cycle Clinical trials Colorectal cancer Combined treatment Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Experiments Gene expression Genetic screening Inactivation Kinases Lung cancer Lung diseases Medicine and Health Sciences Metastases Morphology Research and Analysis Methods Senescence Tumor cell lines Xenografts Xenotransplantation Netherlands
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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